Project Grant R01HL179005

Award Date 6/25/25
Completion Date 3/31/30
Dollars Obligated $820K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
New York, USA
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This Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) will support research by New York University School of Medicine to investigate the use of HLA eplet mismatch (EMM) as a biomarker for assessing immunologic risk in heart transplant recipients. The $819,532 award, effective June 25, 2025 through March 31, 2030, will enable the researchers to:

  1. Use a national dataset to impute high-resolution HLA genotyping and evaluate the association of EMM with rejection, re-transplantation, and mortality in a large cohort of heart transplant recipients.

  2. Assess the relationship between EMM and cardiac allograft vasculopathy, as well as biopsy-proven rejection, using a protocol heart transplant biopsy dataset.

  3. Examine the association of EMM with early indicators of immunoreactivity, including development of donor-specific antibodies and presence of donor-derived cell-free DNA, in a single-center observational cohort.

The goal of this research is to establish EMM as a valuable biomarker for accurately risk-stratifying heart transplant recipients, which could inform future clinical trials to optimize immunosuppression management and reduce associated morbidity and mortality.

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