The National Heart, Lung, and Blood Institute (NHLBI) awarded a $804,438 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Inova Health Care Services to conduct a study titled "Phenotyping Net Immune State with MicroRNAs in Cardiac Transplantation." The study aims to develop a panel of circulating microRNAs that can predict and monitor complications of over- and under-immunosuppression in heart transplant patients. The goal is to create a non-invasive genomic blood test to guide personalized immunosuppression management and improve long-term survival for heart transplant recipients. This 5-year study will involve a prospective, multi-center cohort of 250 adult heart transplant patients, including a high proportion of Black participants. By identifying microRNA biomarkers linked to immune status, the research seeks to address critical barriers in optimizing immunosuppression and enhancing quality of life for cardiac transplant patients.
Generated 3/25/25, 3:35 AM