Project Grant R01HL178953
- Federal Grant Award Summary Duke University's Office of Research Administration received a $160,040 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 30, 2025, with completion targeted for September 4, 2027. The award funds research investigating the application of Partially Ordered Polypeptides (POPs)—a novel injectable biomaterial scaffold—to improve patient outcomes following...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $959,043 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 5, 2025, with completion targeted for May 31, 2029. The award funds research into mechanistic diversity in biased angiotensin receptor ligands, specifically examining how different ligand classes activate the angiotensin II...
- Federal Project Grant Summary The University of Pennsylvania received a $1.14 million Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective March 20, 2026, with an ultimate completion date of January 31, 2033. This award supports the principal investigator's translational research program applying gene-editing therapeutics to cardiovascular and related systemic diseases. The research builds...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $242,250 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion targeted for August 31, 2027. This feasibility study (R03 mechanism) implements arteriovenous blood sampling techniques to measure regional metabolic changes in the heart and legs during submaximal exercise...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $735,071 Project Grant to Indiana University Indianapolis on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research and development of next-generation dystrophin gene therapy for Duchenne Muscular Dystrophy (DMD), with completion targeted for March 31, 2030. The project deliverables include development of an improved triple vector system...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $165,456 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with completion scheduled for June 30, 2030. This award supports fundamental research investigating the role of protein S-palmitoylation in transforming growth factor beta (TGF-β) signaling and its contribution to...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Sanford Burnham Prebys Medical Discovery Institute a $1.6M Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective July 1, 2026, through March 31, 2028, to develop a single-construct gene therapy for enhanced cardiac repair. The project addresses cardiac fibrosis—a pathological feature common to multiple cardiovascular disease states that currently lacks effective antifibrotic treatment...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $242,250 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 18, 2026, with completion targeted for May 31, 2028. This secondary analysis project addresses physical inactivity, which contributes to 5.4 million excess deaths annually, by investigating genetic predictors of exercise and physical...
- Federal Project Grant Award Summary Case Western Reserve University's Office of Research Administration received a $1.53 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion targeted for May 31, 2028. The award funds research and development of a novel "bait-and-switch" gene therapy delivery platform designed to overcome critical barriers in...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $1,532,545 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 5, 2026, with completion targeted for February 29, 2028. The project examines the effects of income-based health insurance benefit designs on cardiovascular disease (CVD) outcomes and health disparities among working-age adults. Specifically, the...
Duke University received a $814,943 Project Grant from the National Heart, Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2026, with completion targeted for March 31, 2030. The award supports the development of non-viral gene therapy systems for cardiac regeneration following myocardial injury. The research deliverables include: (1) development and in vivo testing of cardiac-targeted lipid nanoparticles (LNPs) designed to transfect cardiomyocytes; (2) adaptation of CELLREADR (Cell Access through RNA Sensing by Endogenous ADAR) technology to enable precise targeting of therapeutic transgenes to injured cardiomyocytes based on specific cellular RNA markers; and (3) proof-of-concept demonstration of non-invasive vascular endothelial growth factor A (VEGFA) delivery via LNPs with conditional CELLREADR transgenes to repair mouse cardiac tissue following ischemia-reperfusion injury. The research outcomes will establish a versatile, cell-type-specific non-viral cardiac gene therapy platform that addresses critical limitations of current adeno-associated virus (AAV)-based approaches, including neutralizing antibody prevalence and limited packaging capacity. This work is designed to produce both methodological advances applicable to multiple disease states and clinically relevant insights regarding optimal delivery strategies for therapeutic VEGFA in cardiac regenerative medicine.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $814.9k | 7/16/26 |