Project Grant R01HL178835

Award Date 6/4/25
Completion Date 4/30/29
Dollars Obligated $844K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), provides $784,206 to the Albert Einstein College of Medicine to study the role of the CSF-1/CSF-1R axis in myocardial infarction (MI) repair and remodeling. The research aims to examine the in vivo effects of macrophage-specific CSF-1R activation, investigate the role of fibroblast-derived CSF-1, explore the therapeutic potential of early CSF-1/CSF-1R axis...
This Project Grant award of $252,854 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) supports research to develop computational tools that can link single-cell RNA sequencing (scRNAseq) data to experimentally-testable predictions about the functional consequences of different cardiomyocyte subtypes. The project combines scRNAseq, mechanistic mathematical modeling, and physiological assays to investigate how...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $667,865 to The Johns Hopkins University to conduct research on the role of microglial glutaminase in HIV-induced sleep disturbances. The research aims to: 1) characterize sleep phenotypes in two murine models of neuroHIV, 2) analyze microglial activation, neuronal activity, neuroinflammation, and microglial transcriptome in these...
This federal Project Grant award of $594,547.00, awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to characterize a gut-to-brain signaling pathway that regulates sleep depth and arousability in response to dietary proteins. The primary awardee, President and Fellows of Harvard College, doing business as Harvard Medical School, will investigate the molecular mechanisms by which dietary proteins are...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), is funding research to examine a neural circuit in the brain that contributes to the adverse cardiovascular effects of chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnea. The research aims to determine how a circuit involving orexin neurons, corticotropin-releasing hormone (CRH) neurons, and neurons in the...
This federal Project Grant award, worth $827,356.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The funding supports a prospective study to determine the imaging response to immune suppressant therapy in patients with active cardiac sarcoidosis. The study aims to establish quantitative thresholds for imaging parameters, such as FDG uptake on PET and advanced cardiac MRI measures, that are associated with...
This $1,088,500 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a research program with three independent projects related to genetic and molecular mechanisms of heart disease. The first project aims to define microRNA targeting events and their biological relevance in the heart, as well as understand the clinical significance of genetic variants that alter cardiovascular microRNA...
This $785,198 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at Albert Einstein College of Medicine to investigate the role of chaperone-mediated autophagy (CMA) in cardiac fibrosis and repair following myocardial infarction. The research aims to study how CMA, a process that selectively degrades specific proteins, regulates the phenotypic transitions and functions of...
This Project Grant award of $133,410 from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the relationship between sleep quality, sleep apnea, and cardiac aging. The study aims to leverage longitudinal sleep data from the Korean Genome and Epidemiology Study to assess how impaired sleep patterns accelerate cardiovascular disease risk over a 12-year period. The research will focus on...
The National Heart, Lung, and Blood Institute (NHLBI) awarded The Trustees of Columbia University in the City of New York a $821,982 Project Grant under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837). The grant, awarded on July 15, 2024, will fund a 5-year research project to investigate variability in sleep timing as a potential new risk factor for cardiovascular disease (CVD) among women. The study will leverage two racially and ethnically diverse cohorts of women...

This Project Grant award of $843,607.00 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), will support research at the Icahn School of Medicine at Mount Sinai to investigate the neuroimmune pathways that regulate sleep after myocardial infarction (MI) and the resulting brain-heart interactions that promote cardiac recovery. The research aims to document how thalamic neuroinflammation after MI leads to the recruitment of TNF-producing monocytes, which augment sleep and restrict sympathetic outflow from the brain to the heart, thereby promoting cardiac healing. The project will utilize murine models and advanced neuroscience, immunology, and cardiology techniques to achieve these goals over the award period from June 4, 2025 to April 30, 2029.

Generated 7/8/25, 1:28 PM