Project Grant R01HL178410

Award Date 7/5/25
Completion Date 4/30/30
Dollars Obligated $620K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Michigan, USA
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The study aims to determine differences in the pharmacodynamic and pharmacokinetic effects of beta-blockers between HFREF patients with low versus high PRS scores. This includes evaluating changes in left ventricular ejection fraction, exercise-induced heart rate, and beta-blocker plasma concentrations. The expected outcomes are a mechanistic understanding and prospective validation of the beta-blocker PRS, which will inform future personalized beta-blocker therapy for HFREF patients. The award period is from July 5, 2025 to April 30, 2030.

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