Project Grant K08HL179262
Award Date
5/15/25
Completion Date
4/30/30
Dollars Obligated
$167K
Federal Agency
National Heart Lung and Blood Institute
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Michigan, USA
Similar Awards
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $692,971 to Case Western Reserve University to conduct a collaborative research project aimed at advancing the understanding of genetic mutations in cardiac myosin binding protein C (cMyBP-C) that can lead to hypertrophic cardiomyopathy. The project integrates molecular biology, biophysics,...
This $194,375 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate how changes in the mechanical properties of the extracellular matrix during cardiomyopathy progression affect cardiomyocyte function and phenotype. The research aims to: 1) Determine if cardiomyopathy-driven extracellular matrix remodeling alters myocardial viscoelasticity, and 2) Assess how matrix...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), will support a $135,840 multiscale computational and experimental investigation of cardiac contractile dysfunction mechanisms in familial cardiomyopathies. The two-year project, starting on September 1, 2024, will focus on understanding how structural perturbations to the myosin motor protein impact its interaction with actin and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $703,358 to Tufts Medical Center Parent, Inc. over the period of August 22, 2024 to May 31, 2028. The award will support research to investigate the role of the FHOD3 gene variant in regulating autophagy pathways and their impact on the development of hypertrophic cardiomyopathy and heart failure. The project will leverage...
The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $730,764 Project Grant to Case Western Reserve University to define the effects of cardiac myosin binding protein C (cMyBP-C) missense variants on cardiac sarcomere structure and function, and link these mechanisms to the development of hypertrophic cardiomyopathy (HCM). The project aims to utilize cryo-electron microscopy, cellular biophysics...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $126,306 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Washington. The grant, awarded on December 20, 2024, will fund research to establish a new high-throughput system for reclassifying genetic variants associated with hypertrophic cardiomyopathy (HCM) and to determine the role of potential genetic modifiers that influence the severity of HCM caused by pathogenic MYH7 gene...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is focused on conducting a deep mutational scan of the MYH7 gene in genome-edited human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The University of Washington is the primary awardee, receiving $2,507,438 over the period of August 5, 2024 to April 30, 2029. The key objectives are to: 1) Generate a single nucleotide...
This $777,258 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to improve the understanding of heart failure in patients with hypertrophic cardiomyopathy (HCM) through novel cardiac MRI imaging techniques. The principal investigator at the Beth Israel Deaconess Medical Center, Inc. (Bidmc) will leverage advanced cardiac MRI technologies, including diffusion tensor imaging, spectroscopy, and...
This $817,208 Project Grant was awarded on January 3, 2025 by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research at the Broad Institute of MIT and Harvard to investigate the genetic basis and underlying mechanisms of heart failure (HF). The project will leverage high-throughput assays, including cell painting and Perturb-seq, to link genes associated with HF risk through genome-wide association...
This federal Project Grant award of $601,563 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate the pathogenic roles and molecular mechanisms of histone lysine demethylases KDM5A and KDM5B in the development and progression of heart failure (HF), with a focus on a specific type of hereditary cardiomyopathy known as lamin-associated dilated cardiomyopathy (LMNA-DCM). The research project, spanning...