Project Grant R01HL177188
- This $726,205 federal Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the development and validation of a new super-resolution intravascular ultrasound (SR-IVUS) technology. The goal is to enable effective imaging of the coronary vasa vasorum network and thin fibrous cap of vulnerable atherosclerotic plaques to better assess plaque vulnerability and prevent acute coronary syndromes. The project involves creating an...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) in the amount of $400,000.00 will fund the development of a new high-speed 3D dynamic contrast microscopic optical coherence tomography (3D DYC-μOCT) system. This advanced label-free imaging technology aims to provide a clearer picture of how airway cells function in health and disease by enabling the 3D visualization of ciliary beating dynamics in human airway organoids without the need for...
- The U.S. National Institutes of Health (NIH) awarded a $3,179,146 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to the California Institute of Technology (Caltech) to develop next-generation photoacoustic computed tomography (PAT) technology. The project aims to push PAT imaging depth from the current limit of 1 mm to 6 cm while maintaining high spatial resolution. Key technical advancements include optimizing signal-to-noise ratio, enhancing ultrasonic...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support the development of an ultrasonically-enhanced swept source optical coherence tomography (UESS-OCT) system for label-free, non-invasive optical imaging inside the human body. The $425,000 award to the Regents of the University of California at Riverside will fund research to utilize ultrasound waves to focus and steer light through tissue, enabling high-resolution structural and...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $366,006 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the Georgia Tech Research Corporation to develop flexible piezo film intravascular ultrasound (IVUS) arrays on guidewires and catheters. The goal is to integrate IVUS imaging capability onto standard guidewires and catheters used in over 1 million percutaneous coronary and peripheral...
- This federal Project Grant award of $747,281 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a real-time, non-invasive technique to characterize the mechanical properties of blood clots (thrombi) as they age. The project aims to utilize ultrasound-responsive nanodroplets that can transition into microbubbles when exposed to focused ultrasound, a process known as acoustic droplet vaporization (ADV). By leveraging ADV, the...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will fund the development of a low-voltage, miniaturized endoscopic micro-optical coherence tomography (MOCT) system. The $405,689 award to the University of Colorado will support the validation of a low-voltage electrowetting prism scanner for high-speed MOCT imaging, as well...
- The federal Project Grant award, valued at $413,595, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports the development of a "Magnetic Rotational Platform for Coronary Lesions" by Unandup, LLC, a technology firm in St. Louis, Missouri. The project aims to create an innovative medical device technology that leverages magnetic fields to improve the treatment of severe coronary artery...
- The federal Project Grant award by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $534,761 to the University of California, Los Angeles (UCLA) to develop "Magnetoelastic Vascular Grafts" (MVGs). The MVGs are a transformative platform technology that can wirelessly and continuously monitor blood flow and detect stenosis (narrowing) in vascular grafts, a common issue affecting nearly 40% of grafts within 2 years of implantation. The...
- The federal Project Grant award of $507,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to develop an automated system that integrates micro-electromechanical sensors, automation, and machine vision to simultaneously measure electrophysiological properties and contractile forces in single human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). This innovative system is expected to significantly reduce measurement time...
This federal Project Grant award from the National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), is for the "Development of Integrated OCT/US/PAT System for Intravascular Imaging". The $617,366 award is being used to develop a multimodal intravascular imaging system incorporating optical coherence tomography (OCT), ultrasound (US), and photoacoustic tomography (PAT) technologies. The objectives are to design and construct a confocal OCT/US/PAT imaging probe, develop the integrated system using advanced laser sources, and demonstrate the efficacy of the proposed system through in vivo testing in a porcine model. This project aims to provide physicians with a powerful clinical instrument for studying, diagnosing, and managing vulnerable plaques associated with coronary artery disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $617.4k | 8/13/25 |