The Regents of the University of California, San Francisco (UCSF) received a $684,814 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant, awarded on January 1, 2025, supports research aimed at understanding how tissue factors in the lung alter the inflammatory response to viral infections and suppress alveolar type 2 stem cells in emphysema, a subtype of chronic obstructive pulmonary disease (COPD). The research leverages novel genetic tools, human lung organoid models, and single-cell analyses to elucidate the mechanisms by which tissue-resident lymphocytes accumulate in the lungs and suppress the regenerative capacity of alveolar stem cells. The ultimate goal is to identify potential pharmacological interventions to mitigate the loss of lung function and frequent exacerbations associated with COPD.
Generated 3/4/25, 3:45 AM