Project Grant R01HL176972
- The National Heart, Lung, and Blood Institute awarded New York University $331,344 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on heart donor selection and utilization. The research addresses two primary barriers limiting U.S. heart transplant volume: insufficient evidence on which donor risk factors impact outcomes, and difficulty synthesizing clinical data during donor selection. The study will investigate the impact of specific...
- The National Heart, Lung, and Blood Institute awarded The University of Chicago $817,976 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop single molecule footprinting methods for studying gene regulation in cardiac differentiation and disease. The recipient will combine methyltransferase-based chromatin measurement with native long-read sequencing to assess chromatin accessibility, nucleosome positioning, transcription factor binding, and DNA...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $1,597,024 under the Cardiovascular Diseases Research program (CFDA 93.837) on July 1, 2026, to investigate mitochondrial quality control mechanisms in donor heart endothelial and smooth muscle cells as a strategy to improve cardiac allograft survival and reduce cardiac allograft vasculopathy following heart transplantation. The research addresses the acute and chronic phases of transplant injury:...
- The National Heart, Lung, and Blood Institute awarded The University of Chicago $642,477 on June 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a targeted quality improvement trial improving post-discharge venous thromboembolism (VTE) chemoprophylaxis following abdominal and pelvic cancer surgery. The trial addresses the gap between clinical evidence and practice adoption. Randomized trials have demonstrated that chemoprophylaxis extending beyond...
- Federal Grant Award Summary The University of Chicago received a $762,950 Project Grant award dated September 15, 2025, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of matrix metalloproteinase-3 (MMP3) in cardiac microvascular barrier dysfunction during sepsis. The research aims to elucidate the endothelial B1R/MMP3 pathway's contribution to sepsis-induced cardiac dysfunction (SICD), a...
- The National Heart, Lung, and Blood Institute awarded New York University a Project Grant of $847,373 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The project will use national organ transplant registry data, including structured clinical data and unstructured narratives describing donor chest imaging findings, to improve evidence for lung offer decisions in transplantation. Large language models will be trained to extract structured data elements from...
- The National Heart, Lung, and Blood Institute awarded the University of Illinois $109,076 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop individualized prediction methods for heart failure progression using digital twins and explainable reinforcement learning. The project will characterize cardiac performance at the individual level using primary echocardiographic images, quantitative echocardiographic measures, and arterial pulse wave velocity...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $696,259 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop flexible electronics and optogenetics approaches for real-time arrhythmic profiling of engineered heart tissues. The project runs through April 30, 2031, with work performed in Chicago, Illinois. The award funds development of non-invasive arrhythmia assessment methods for human induced pluripotent stem cell–derived...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $105,476 for a Project Grant (CFDA 93.837, Cardiovascular Diseases Research) on January 25, 2027. The award funds research addressing two critical shortcomings in the current donor heart allocation system. The project develops data-driven policy solutions to improve the prioritization of candidates with durable left ventricular assist devices (LVADs), which extend time on mechanical support but are...
- The National Institutes of Health National Heart Lung and Blood Institute awarded Ann & Robert H Lurie Children's Hospital of Chicago $876,614 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a multisite prospective cohort study advancing acute respiratory infection treatment in pediatric invasive home mechanical ventilation. The research will enroll 400 children in English and Spanish language families using long-term home mechanical...
The National Heart, Lung, and Blood Institute awarded The University of Chicago $1,368,536 on August 13, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop fair and efficient allocation algorithms for continuous distribution of donor hearts in transplantation. The project addresses critical gaps in the current therapy-based heart allocation system, which the recipient has demonstrated to be vulnerable to manipulation, sensitive to treatment practice changes, and inefficient at identifying candidates with the highest survival benefit from transplantation. The work will develop accurate and fair prediction models for medical urgency and post-transplant survival using the Scientific Registry of Transplant Recipients database. The recipient will improve preliminary medical urgency scoring for adult candidates, extend the approach to pediatric candidates, address evolving mechanical circulatory support technology, prevent score manipulation, and conduct real-world evaluation. The project will also design a waiting time points solution for durable left ventricular assist device allocation analogous to current kidney allocation hemodialysis waiting time systems. Performance occurs in Chicago, Illinois with a period extending through April 30, 2028. The award is classified as a Project Grant, a mechanism supporting discrete research projects under the NHLBI's mission to foster heart and vascular research in basic, translational, clinical, and population sciences.
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