This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $717,236 to The University of Iowa to study the role of neuronal primary cilia in hypertension, autonomic dysfunction, and body fluid imbalance. The goal is to evaluate how conditional ablation of cilia in the supraoptic nucleus affects blood pressure, drinking, urine volume, sodium concentration, plasma osmolality, regional sympathetic...
This federal Project Grant award of $332,862.00 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, will support research to assess night-to-night variability in novel sleep disordered breathing severity metrics and their impact on daytime functioning. The study aims to characterize reliable biomarkers of obstructive sleep apnea (OSA) severity, as the current standard measure (Apnea-Hypopnea Index) underestimates...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $421,800 to Midwestern University to explore the effects of chronic intermittent hypoxia on cholinergic modulation at hypoglossal motoneurons. The project aims to determine changes in muscarinic acetylcholine receptor expression and cholinergic inputs to hypoglossal motoneurons in neonatal and adult mice exposed to chronic...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the Cardiovascular Diseases Research program (CFDA 93.837), provides $711,226 to the University of California, Los Angeles (UCLA) to conduct research on the impacts of obstructive sleep apnea (OSA) on the brain. The objectives are to: 1) examine regional brain temperatures in OSA patients compared to controls; 2) assess whole-brain metabolite and antioxidant levels in OSA and controls; 3)...
This Project Grant award of $673,512.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco. The funding will support research to determine the cellular mechanisms underlying the subconscious pacing of breathing, with the goal of advancing the understanding of breathing physiology and potentially enabling new approaches to treat breathing disorders like...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,415,112 project grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Nebraska Medical Center (UNMC) to evaluate a telehealth-delivered adaptive intervention for improving continuous positive airway pressure (CPAP) therapy adherence and health outcomes in adults with obstructive sleep apnea (OSA). The project aims to: 1) compare effects of motivational enhancement, device support, and...
This Project Grant award of $696,470.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Denver to investigate the relationship between prenatal maternal sleep and offspring cardiovascular disease risk. The research aims to: 1) examine how prenatal maternal sleep trajectories predict maternal biological pathways like inflammation and stress, 2) assess how prenatal maternal sleep impacts offspring growth,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $498,991.40 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Arkansas. The grant, effective January 2, 2025 through December 31, 2027, will support the development of microphysiological systems to investigate molecular pathways and cardiomyocyte function in response to hypoxic cardiac injury associated with myocardial infarction and ischemia-reperfusion injury. The project aims to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $162,728 to the University of California, San Diego (UCSD) to conduct research on the cardiovascular impacts of comorbid obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD), known as overlap syndrome (OVS). The central hypothesis is that poor outcomes in OVS are driven by more pronounced right and left heart...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $744,305 to the University of Virginia to conduct research on the molecular physiology and connectivity of CO2/H+-sensitive brainstem neurons located in the retrotrapezoid nucleus (RTN). The key goals of the research are to: 1) Examine how persistent expression of the transcription factor PHOX2B regulates genes critical for the RTN...