Project Grant R01HL179183
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $165,672 to New York University School of Medicine to conduct research aimed at increasing heart transplant utilization in the United States. The key objectives are to: 1) investigate the impact of donor risk factors such as coronary artery disease, left ventricular dysfunction, and older age on heart transplant outcomes, and 2) develop prediction models...
- This federal Project Grant award, valued at $174,420.00, was granted by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award will support research by the University of Pennsylvania to investigate the impact of ongoing centralization of deceased organ donor management on lung transplantation outcomes. The study aims to analyze the effects of transferring deceased donors from hospitals to specialized regional Donor Care...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $200,000.00 to New York University School of Medicine to conduct a case-cohort study investigating novel determinants of risk for living kidney donors. The key objectives are to: 1) use qualitative research to inform recruitment strategies and messaging to maximize participation of...
- This Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research, seeks to characterize circadian rhythms in organ donors and identify mechanisms by which donor and recipient circadian clocks affect transplant acceptance. The $1,411,136 award, with a performance period from December 16, 2024 to November 30, 2028, will fund research focused on the lung, as long-term survival after lung transplantation remains...
- The Project Grant award of $784,227 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The Ohio State University supports research to engineer an oxygen-carrying perfusate for normothermic machine lung perfusion. The goal is to address the critical shortage of viable donor lungs for transplantation by improving the assessment and potential resuscitation of donor lungs, particularly those from donation after circulatory death (DCD). The research...
- This $272,226 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support a novel study to optimize ICU interprofessional team composition for mechanically ventilated adults. The research aims to determine how clinician and scheduling characteristics impact patient outcomes, and explore how patient characteristics moderate these relationships. The study will leverage a unique dataset linking electronic health records from...
- This federal Project Grant award of $229,553 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a mixed-methods study to understand the impact of non-clinical donor factors on post-donation follow-up care for living kidney donors. The study aims to identify barriers such as limited access to care, financial strain, and distance from transplant centers that...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides funding of $739,562 for research into the epigenetic regulation of donor heart preservation mediated by the protein BRD4. The principal investigator will determine how factors such as increased osmolality, cold perfusion, and expression of splicing mediators contribute to increased expression of the short isoform of BRD4 during cold cardiac preservation. This...
- The federal Project Grant award titled "DEATH ONE HOUR AFTER TERMINAL EXTUBATION (DONATE) 2.0 STUDY" is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $286,820 award to Children's Hospital Los Angeles (CHLA) aims to validate the performance of the DONATE machine learning model at predicting whether a patient will die within one hour after...
- This federal Project Grant award of $860,513 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to conduct a detailed analysis of the long-term health outcomes of living kidney donors using a comprehensive national electronic health records dataset. The goal is to understand how reduced kidney function after donation impacts the health of living kidney donors compared to the general...
This federal Project Grant award of $762,747.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at New York University School of Medicine to develop engagement protocols for donor family members and healthcare staff involved in research on the recently deceased maintained physiologically following declaration of death by neurologic criteria (DNC research). The research aims to understand the experiences, attitudes, and perceptions of DNC research stakeholders, including donor families and healthcare staff, in order to develop guidelines and consensus approaches for obtaining DNC research authorization and addressing concerns related to issues such as the definition of brain death, zoonotic disease risks, prioritization of clinical care versus research, and respectful treatment of the body. This research has the potential to advance the use of DNC research as a translational model for studying interventions like xenotransplantation, novel pharmaceuticals, and gene therapies, while addressing ethical and operational challenges that could impact donor availability and trust in this emerging research area.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $762.7k | 8/22/25 |