Project Grant R01HL176849
- The University of Pittsburgh was awarded a $633,045 project grant by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the pathogenic mechanisms and therapeutic approaches for exercise intolerance in post-acute sequelae of COVID-19 (PASC). The project aims to elucidate the molecular drivers of exercise intolerance in PASC patients, leveraging the university's expertise in evaluating PASC patients at their post-COVID recovery clinic. Key...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
- This Project Grant award of $147,486 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to investigate the role of inflammatory signaling in the migration and function of ectopic KRT5+ cells during severe respiratory viral injuries. The research will assess whether canonical NF-kB signaling is necessary for the expansion and migration of these ectopic cells, which have been associated with the development of pulmonary fibrosis following viral...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $234,000.00 to Oregon Health & Science University (OHSU) to evaluate circulating viral and host microRNA (miRNA) signatures in SARS-CoV-2 infections. The project aims to shed light on miRNAs that can serve as systemic biomarkers to aid in stratifying patients and identifying those with active herpesvirus infections, such as Epstein-Barr virus (EBV), which have...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) provides $175,428 to The Trustees of the University of Pennsylvania to investigate the mechanisms and potential therapeutic targets for "Long COVID". The key objectives are to: 1) Determine how SARS-CoV-2-specific CD8 T cells respond to viral reservoirs in Long COVID patients, 2) Assess whether therapies that suppress SARS-CoV-2 replication...
- The federal Project Grant award of $108,978.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms underlying the age-related decline in the regenerative capacity of alveolar type 2 (AT2) cells in the lung. The principal investigator and research team at the Harvard T.H. Chan School of Public Health will conduct studies to determine whether elevated interferon gamma (IFNG) levels and changes in resident...
- This Project Grant award for $814,387 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research to investigate the role of a novel subpopulation of innate lymphoid cells (ILC3s) in lung infections and vascular regeneration. The award recipient, The Trustees of Columbia University, will utilize mouse models, single-cell analysis, and in vitro assays to: Define the tissue niche and response dynamics of lung vascular ILC3s (VILC3s),...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $759,983.00 to the University of North Carolina at Chapel Hill to conduct research on the role of neutrophils in lung infections and acute lung injury. The study aims to examine changes in neutrophil transcriptomes and function during Streptococcus pneumoniae pneumonia, with the goal of improving understanding of the lung's immune response and potential...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $701,795 to The Trustees of the University of Pennsylvania to conduct research aimed at defining the cardinal functions of lung progenitors during regeneration. The 4-year project, which began in September 2025, utilizes a multi-modal approach including cell lineage tracing, single-cell analysis, histological spatial analysis, and cross-species comparison to...
- This federal Project Grant award from the Department of Health and Human Services National Institutes of Health Office of the Director provided $14,427,699 to New York University School of Medicine for the period of May 24, 2021 through May 23, 2022. The award was made under the Lung Diseases Research program (CFDA #93.838) to support the POST-ACUTE SEQUELAE OF SARS-COV-2 INFECTION INITIATIVE: NYU LANGONE HEALTH CLINICAL SCIENCE CORE, DATA RESOURCE CORE, AND PASC BIOREPOSITORY CORE....
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $754,729 to the University of Pittsburgh to investigate the mechanisms by which respiratory viral infections, including COVID-19, can lead to persistent lung inflammation and damage. The research aims to understand how viral antigen persistence in pulmonary endothelial cells drives chronic activation of CD8+ T cells, leading to long-term pulmonary sequelae. The project will employ mouse models of SARS-CoV-2 and influenza virus to examine these pathways and confirm findings using human patient samples. This work seeks to advance the understanding of the molecular underpinnings of "Long COVID" and "Long Flu" to inform the development of potential therapeutic interventions effective across a range of respiratory viral infections. The award period runs from August 10, 2025 to May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $754.7k | 8/7/25 |