Project Grant R01HL176528

Award Date 9/25/24
Completion Date 6/30/29
Dollars Obligated $1.3M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90024, USA
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This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) totals $1,251,718 and will be executed from September 2024 through June 2029. The primary objectives are to:

  1. Determine the impact of HIV co-infection on cardiopulmonary function in individuals who have completed treatment for pulmonary tuberculosis (TB), including assessments of pulmonary function tests, echocardiography, 6-minute walk test, and validated questionnaires.

  2. Examine the mechanisms underlying cardiorespiratory fitness in a subset of participants through cardiopulmonary exercise testing.

  3. Identify phenotypic clusters and biomarkers that may explain the different cardiopulmonary disease patterns observed in the post-TB population, with and without HIV co-infection.

This longitudinal cohort study will enroll 480 individuals in Kampala, Uganda who have completed TB treatment, along with 120 healthy comparators, in order to elucidate the prevalence, trajectory, and underlying mechanisms of cardiopulmonary abnormalities following TB. The study aims to develop a well-characterized post-TB cohort to enable future mechanistic studies, targeted interventions, and improvements in clinical care.

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