This Project Grant award of $759,983 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the University of North Carolina at Chapel Hill supports research examining the diverse responses of neutrophils during Streptococcus pneumoniae pneumonia and acute lung injury. The research aims to determine changes in neutrophil transcriptomes and the lung microenvironment during the development and resolution of S. pneumoniae-induced inflammation and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,063,324 to Tulane University to conduct research on CD4+ T cell immunity in the respiratory tract. The research aims to shed new light on pulmonary host defenses that can be leveraged to reduce the global burden of pneumonia mortality and morbidity. Specifically, the project will use murine and primate respiratory tract samples to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,659,996 to the University of Southern California (USC) from April 1, 2025 to January 31, 2029. The funding supports research to investigate the role of the protein PDLIM2 in regulating alveolar macrophage function, which is critical for lung innate immunity, inflammation, and respiratory diseases. The research aims to elucidate the...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $656,988 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to study the role of HMGB1 in the lung's response to bacterial injury. The objective is to develop a therapeutic strategy to replace a failed component of the macrophage lung injury response and enable healing in patients with...
This $163,080 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support a multidimensional analysis of the regulatory T cell (Treg) response in children with severe viral pneumonia. The primary investigator will conduct research to determine if Treg cells have impaired reparative functions during severe viral pneumonia in juvenile mice, investigate how the age-specific lung microenvironment affects...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $579,309 to the University of Toledo's Health Science Campus Division to conduct research on the role of cysteinyl leukotriene receptor signaling in regulating macrophage function and lung inflammation. The research aims to elucidate the mechanistic aspects of how the CYSLT1R receptor promotes an inflammatory macrophage phenotype,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,831,848 to the University of Rochester to investigate how neonatal microbiome colonization impacts lung immunity and regeneration. The research aims to elucidate how early-life microbial dysbiosis remodels the developmental program in lung-resident lymphocytes and epithelial cells, contributing to chronic respiratory disease. Key...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $880,735 to the University of Washington to investigate the mechanisms by which cell lysis and the release of lipid mediators like leukotriene C4 (LTC4) and leukotriene D4 (LTD4) activate type-2 immune responses in the lung. The research aims to elucidate how this process, mediated by alveolar macrophages, contributes to the...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $392,660 Project Grant under CFDA Program 93.837 - Cardiovascular Diseases Research to the University of Pennsylvania to investigate the role of red blood cells (RBCs) in regulating the immune response during sepsis. The research aims to: 1) establish the subcellular localization of Toll-like Receptor 7 (TLR7) in human RBCs and determine their RNA-sequestration capabilities during sepsis; 2) determine the role of RBC-TLR7 in...
This federal Project Grant award, totaling $756,875.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Cincinnati. The award supports research to investigate the fundamental mechanisms by which neutrophil extracellular traps (NETs) contribute to airway damage and infection in mucoobstructive lung diseases, such as cystic fibrosis. Key research aims include examining how NET-mediated...