Project Grant R01HL175157
- The federal Project Grant award of $760,374 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research by National Jewish Health to develop predictive molecular signatures for diagnosing sarcoidosis and identifying patients at risk of disease progression. The project will integrate single nucleotide polymorphisms, gene expression, and plasma metabolomics/lipidomics data using advanced machine learning to identify potential biomarkers....
- The National Heart, Lung, and Blood Institute awarded a $249,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to National Jewish Health to identify common and distinct metabolic and proteomic pathways associated with inflammation and fibrosis in pulmonary sarcoidosis. The 2-year project aims to use plasma specimens to characterize metabolic and proteomic profiles that differentiate fibrotic and non-fibrotic pulmonary sarcoidosis phenotypes and endotypes. This...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $451,734 to The University of Iowa to conduct research on the role of residential bioaerosol exposure in pulmonary sarcoidosis. The project aims to determine the association between residential bioaerosol exposure and the severity of pulmonary sarcoidosis, investigate the impact of bioaerosol on immune dysregulation in fibrotic...
- The University of Washington received a $663,578 Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective August 15, 2025 through May 31, 2029, supports research to better diagnose and understand cardiac sarcoidosis, a form of inflammatory cardiomyopathy. The project aims to "perform 'deep phenotyping' with genetic testing, PET imaging, metabolomic studies, and voltage-guided endomyocardial...
- This federal Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $173,480.00 to the University of Illinois to elucidate the mechanisms through which circulating CD14+ monocytes drive the inflammatory-fibrotic axis of advanced pulmonary sarcoidosis-related fibrosis (APSF). The award aims to use single-cell RNA sequencing and surface protein indexing to identify key regulators and signaling pathways within...
- This $793,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to define the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidity. The grantee, Oklahoma Medical Research Foundation, will conduct systematic, high-throughput studies in macrophages derived from induced pluripotent stem cells to identify genetic variants that disrupt regulatory...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) is supporting the development of a peptide-based ELISA diagnostic test for sarcoidosis, a systemic inflammatory disease affecting around 200,000 patients in the U.S. and over 1 million worldwide. The $508,178 award to Kephera Diagnostics LLC, a for-profit company based in Framingham, Massachusetts, aims to address the critical need for a non-invasive diagnostic tool to...
- This federal Project Grant award for $300,000.00 was provided by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The award was granted to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to support the research project "INNATE LYMPHOID CELLS AND TERTIARY LYMPHOID STRUCTURES IN SARCOIDOSIS". The project aims to advance...
- This Project Grant award for $702,103 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to systematically define the signaling pathways by which the protein SFTA2 interacts with the receptor ADGRF5 to control pulmonary surfactant homeostasis. The awardee, National Jewish Health, a non-profit research center in Colorado, will use cell-based assays and mouse genetics to test the hypothesis that SFTA2 regulates alveolar surfactant...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance precision medicine for Acute Respiratory Distress Syndrome (ARDS) and sepsis. The $2,295,984 award to the University of California, San Francisco (UCSF) will fund research to address critical unanswered questions about the distinct molecular phenotypes of ARDS and sepsis, and how to optimize real-time phenotyping and integrate analyses of phenotype-specific...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $778,266 to the Oklahoma Medical Research Foundation (OMRF) to conduct comprehensive research on sarcoidosis. The key objectives are to: Distinguish sarcoidosis patients from healthy and other immune-mediated disease controls using high-throughput plasma proteomics on over 2,000 participants. Identify biomarkers to distinguish sarcoidosis patients with high disease burden from those with low burden. Elucidate the mechanisms underlying the systemic immune dysregulation and tissue-specific inflammatory response in sarcoidosis. The 4-year award period runs from August 1, 2025 through June 30, 2029. This research aims to advance the understanding of sarcoidosis susceptibility and disease burden through an innovative, integrative multi-omic approach leveraging OMRF's expertise in genetics, genomics, and bioinformatics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $778.3k | 8/1/25 |