Project Grant R01HL174945

Award Date 7/15/25
Completion Date 4/28/29
Dollars Obligated $696K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Pensilvania, EE. UU.
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  1. Evaluating the functional, geometric, and histopathologic effects of injecting three different thermoresponsive hydrogel formulations into an ICM porcine model to reduce ventricular wall stress and preserve cardiac function.

  2. Developing a surgical robotic system for safe, spatially controlled, and minimally invasive delivery of the hydrogels to the ventricular wall, leveraging innovations like navigation based on 3D MRI, intraprocedural detection of coronary vasculature, and optimization of injection patterns.

  3. Building patient-specific finite element models to optimize hydrogel injection patterns that can maximally reduce wall stress based on the infarct architecture, and validating this approach in a new set of infarcted pigs.

The award period runs from July 15, 2025 to April 28, 2029, with the goal of advancing a new treatment to interrupt the negative cardiac remodeling that leads to end-stage heart failure.

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