Project Grant R01HL174461

Award Date 6/5/25
Completion Date 3/31/30
Dollars Obligated $721K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
New York, USA
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The research aims to establish whether a diurnal window of arrhythmia vulnerability exists in a swine model of chronic coronary artery disease, investigate the extent of cardiac circadian misalignment in this model, and determine if pharmacological circadian realignment can reduce arrhythmia incidence. The project will also validate the findings using donor human hearts. Successful completion of this research is expected to provide insights into the impact of circadian misalignment on arrhythmia vulnerability and identify potential pharmacological interventions to manage cardiac arrhythmias. The award period is from Jun 5, 2025 to Mar 31, 2030.

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