This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to uncover the prevalence and biological roles of protein arginylation, a critical post-translational modification, in cardiovascular development and disease. The $633,720 award, effective January 25, 2025 through November 30, 2028, aims to: 1) establish a chemical proteomics platform to comprehensively profile arginylation sites in cardiac cell and...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $500,089.80 to the University of Pittsburgh to investigate the role of macrophages in heart failure with preserved ejection fraction (HFPEF). The research aims to uncover the mechanisms by which inflammatory macrophages cause cardiac remodeling in HFPEF at the cellular, molecular, and functional levels. Specifically, the project will investigate how inflammatory...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,408,580 to evaluate the AMPK-BACH1-NRF2 signaling pathway as a potential therapeutic target for inherited dilated cardiomyopathy (DCM). The primary objective is to investigate whether activating this pathway can restore contractile function in human induced pluripotent stem cell cardiomyocytes with DCM-causing mutations, and whether it can mitigate clinical...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $119,250 to the University of Pittsburgh to investigate the role of METTL14-mediated mRNA methylation in regulating postnatal cardiac development and maturation. The research aims to test the hypothesis that METTL14-mediated mRNA methylation orchestrates cardiomyocyte maturation through signaling pathways involving BMP2/10 and...
This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $817,208 to the Broad Institute of MIT and Harvard to study the genetic basis and underlying mechanisms of heart failure. The award will leverage high-throughput functional genomic assays, including cell painting and Perturb-seq, to systematically link genetic risk loci associated with heart failure to specific molecular and cellular...
This Project Grant award of $771,750 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of California, Los Angeles (UCLA) to investigate the role of macrophages in regulating cardiac muscle metabolism after myocardial infarction. The key goals are to: Examine how macrophages recruited to the infarcted heart disrupt cardiac muscle metabolism and decrease NAD pools, which are critical for cardiac energetics....
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $751,747 project grant under CFDA 93.837, Cardiovascular Diseases Research, to the University of North Carolina at Chapel Hill. The grant, titled "CARM1-Mediated Transcriptional and Posttranscriptional Regulation of Cardiomyocyte Maturation," will fund research to define key factors and signaling pathways that regulate the maturation of cardiomyocytes, the primary cells responsible for cardiac contraction. The project aims...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $777,258 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Beth Israel Deaconess Medical Center, Inc. (BIDMC) on February 25, 2025. The grant's objective is to "UNRAVEL THE MECHANISM OF HEART FAILURE IN HYPERTROPHIC CARDIOMYOPATHY WITH EXERCISE CMR", leveraging advanced cardiac magnetic resonance imaging (CMR) techniques to better characterize the pathophysiology of heart failure in hypertrophic...
The National Heart, Lung, and Blood Institute awarded a $1,545,248 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Pennsylvania. The 5-year grant, effective August 1, 2024, will support a prospective observational study of 175 patients to investigate the longitudinal association between post-infarct lipomatous metaplasia (LM) and malignant arrhythmia. The research aims to define the relationship between reperfusion injury, LM...