Project Grant R01HL173893
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $449,625 to Trustees of Boston University to explore the role of circular RNAs in aging-related sepsis and organ damage. The research aims to determine the function and mechanisms of an aging-induced circular RNA, circ20033, in promoting pro-inflammatory activation of macrophages and lung inflammation after bacterial infections, particularly in older adults. The two-year project will...
- This federal Project Grant award, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), will support research at Trustees of Boston University's Medical Campus to investigate the role of circular RNA in host defense against bacterial sepsis and lung injury. The $1,635,000 award, effective April 1, 2025 through March 31, 2029, will fund advanced biomedical research aimed at transforming healthcare for military personnel and the broader...
- The federal Project Grant award of $676,748.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research to extend neutrophil survival in neutropenia-related pneumonia. The goal is to explore an alternative strategy for treating and preventing neutropenia-related pneumonia by increasing the lifespan of neutrophils in the lungs of neutropenic patients. Specifically, the research will investigate the role and regulation of gasdermin D...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $759,983.00 to the University of North Carolina at Chapel Hill to conduct research on the role of neutrophils in lung infections and acute lung injury. The study aims to examine changes in neutrophil transcriptomes and function during Streptococcus pneumoniae pneumonia, with the goal of improving understanding of the lung's immune response and potential...
- This Project Grant award of $392,660 from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) aims to investigate the role of red blood cells (RBCs) in regulating the inflammatory response during sepsis. The key research objectives are to: 1) establish the subcellular localization of Toll-like Receptor 7 (TLR7) in human RBCs and determine their RNA-sequestration capabilities during sepsis, 2) determine how RBC-expressed TLR7 delivers RNA to...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Temple University provides $683,299 to conduct research on the functional immune phenotypes of sepsis patients. The project aims to integrate microphysiological assays, omics data, and in silico modeling to better understand how different neutrophil subpopulations and their interactions with the vascular endothelium contribute to sepsis-induced organ dysfunction....
- This $234,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Thomas Jefferson University to characterize the expression pattern of circulating short non-coding RNAs (sncRNAs) as potential biomarkers for chronic obstructive pulmonary disease (COPD). The researchers will obtain plasma samples from the SPIROMICS study to quantify the levels of two specific sncRNAs, IMMR-Val and IMMR-His, that were previously...
- The Project Grant award titled "STRESS-INDUCED TRNA-DERIVED SMALL RNAS IN CARDIAC FIBROSIS" is funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) in the amount of $739,474.00. The award, with a performance period from August 18, 2025 to May 31, 2030, supports research conducted by The General Hospital Corporation (Massachusetts General Hospital) to investigate the anti-fibrotic roles of a tRNA-derived small RNA (ASP-GTC-3'TDR) in...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $656,988 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to enable new therapies for bacterial pneumonia. The objective of this 5-year project is to develop a therapeutic strategy that can replace a failed component of the macrophage lung injury response and allow healing in patients with...
- This federal Project Grant award of $710,302 from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program aims to investigate the origin and characterize the functional state of the lung interstitial neutrophil (LIN) subset. The project seeks to advance the understanding of the function, fate, pathophysiological role, and origin of LINs, and explore their therapeutic potential. The research will be conducted by Brigham & Women's...
This $245,250 federal Project Grant was awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Trustees of Boston University, doing business as Boston University Medical Campus, to conduct research on the role of circular RNAs (circRNAs) in regulating inflammation and organ injury in response to bacterial pneumonia or sepsis. The key products and services to be delivered under this 4-year grant, which runs from September 1, 2025 to May 31, 2029, include: 1) Identifying highly induced circRNAs, such as circRNA-30884, in response to infectious stimuli in the lungs; 2) Determining the regulatory mechanisms governing circRNA biogenesis; and 3) Evaluating the functional impact of modulating key circRNAs, such as circRNA-30884, on inflammatory cytokine secretion and macrophage pyroptosis, both in vitro and in vivo using exosome-based antisense oligonucleotide delivery. The overall goal is to gain novel mechanistic insights into how circRNAs regulate host immune responses and organ injury during severe bacterial infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $245.3k | 8/28/25 |