Project Grant R01HL173837

Award Date 5/20/25
Completion Date 2/28/29
Dollars Obligated $816K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Texas, USA
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The National Heart, Lung, and Blood Institute (NHLBI) awarded a $816,079 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Texas Health Science Center at Houston (UTHealth). The grant supports a research project titled "Proteomic Profiling of Heart Failure in Hispanics/Latinos" with a performance period from May 20, 2025 to February 28, 2029.

The project aims to identify protein biomarkers associated with cardiac dysfunction and heart failure risk in Hispanic/Latino populations through state-of-the-art proteome profiling. The researchers will leverage data from the NHLBI-sponsored Hispanic Community Health Study/Study of Latinos (HCHS/SOL) to achieve the following objectives: 1) Identify circulating proteins and protein signatures associated with impaired cardiac function and its progression; 2) Identify circulating proteins and protein signatures that predict the development of clinical heart failure; and 3) Identify genetic determinants of heart failure- and cardiac function-related proteins, and determine how genetic variations relate to cardiac dysfunction and heart failure. The findings are expected to provide insights into the biological pathways underlying progressive cardiac dysfunction and heart failure, as well as identify potential targets for drug development.

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