Project Grant R01HL173594
- The National Heart Lung and Blood Institute, under its Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $412,250 project grant to Arizona State University (ASU) to develop a real-time, automated smart catheter analyzer for early identification of sepsis through continuous monitoring of urine biomarkers. This non-invasive approach aims to enable rapid sepsis diagnosis, within 200 minutes, to support quick clinical intervention and preservation of heart and lung...
- This Project Grant award of $750,561 from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund the SMART-SEPSIS study. The study aims to use electronic health record data and artificial intelligence/machine learning to model individual patient response to sepsis treatment and promote early but reasoned application of the hour-1 sepsis treatment bundle for patients with suspected community-onset lung sepsis. The goal is...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is providing $174,960 to the Regents of the University of Michigan to develop and evaluate a personalized approach to initial fluid resuscitation for patients with hospital-onset sepsis. The key products and services to be delivered under this award include: 1) an electronic health record-based cohort study to understand the impact of initial fluid volume on outcomes in...
- This Project Grant award of $455,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decrease sepsis mortality in the pediatric population. The key products and services to be delivered include: Developing an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Performing sepsis phenotyping and creating digital twin patient models to predict personalized treatment responses....
- This federal Project Grant award from the National Institute of Nursing Research (NINR), under the Nursing Research CFDA program (93.361), provides $144,691 to the University of Pennsylvania to conduct a qualitative descriptive study on sepsis patient education within home healthcare settings. The study aims to generate foundational knowledge on how home health nurses provide sepsis-related patient education to sepsis survivors and to understand sepsis survivors' perspectives on their...
- The federal Project Grant award of $783,661.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a pragmatic, randomized clinical trial to evaluate the effectiveness and safety of oral midodrine as a vasopressor-sparing agent in patients with sepsis-associated hypotension. The study, conducted by the Mayo Clinic, aims to provide an alternative to intravenous vasopressors and reduce the burden of intensive care unit (ICU) stays for these...
- This federal Project Grant award of $423,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, aims to address two critical challenges related to burn sepsis: Identifying distinct immune response phenotypes after burn injury and their relation to sepsis development, in order to enable novel approaches to mitigate sepsis risk. Determining the mechanism by which elevated angiopoietin-2 (ANGPT-2) leads...
- This Project Grant award, in the amount of $187,410, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant will support Dr. Hilary Faust, an early-career physician-scientist, in developing novel approaches to identify and target sepsis-associated endothelial dysfunction. The funding will enable Dr. Faust to master advanced techniques for modeling human sepsis-associated endothelial injury...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Temple University provides $683,299 to conduct research on the functional immune phenotypes of sepsis patients. The project aims to integrate microphysiological assays, omics data, and in silico modeling to better understand how different neutrophil subpopulations and their interactions with the vascular endothelium contribute to sepsis-induced organ dysfunction....
- The University of Iowa was awarded a $612,186 Project Grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the role of the lysosome in heart failure with preserved ejection fraction (HFPEF). The project aims to determine the pathophysiological impact of cardiac lysosomal dysfunction in HFPEF, which accounts for half of heart failure hospitalizations in the U.S. The research will investigate how the lysosomal protein GILT...
The federal Project Grant award titled "Characterizing a High-Reliability Implementation Program for Sepsis: Sepsis Tools and Accurate Reporting of Outcome Differences (STANDARD) Study" is funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) for $814,313. The award, with a performance period from Aug 1, 2025 to May 31, 2029, aims to identify organizational features and performance improvement implementation practices that can reduce sepsis mortality in hospitals. The key products and services to be delivered under this grant include: The grant recipient is the University of Iowa, a prominent public research university with extensive experience in federal contracting and grant work, particularly in the areas of medical research and healthcare services.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $814.3k | 7/25/25 |