Project Grant R01HL173090
- The University of Alabama at Birmingham (UAB) was awarded a $539,342 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the circadian mechanisms governing cardiac growth. The project aims to investigate how the cardiomyocyte circadian clock regulates cardiac processes, particularly the branched chain amino acid catabolism and mTOR activation during the active and sleep periods. This research seeks to advance...
- The federal Project Grant award of $535,556.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Alabama at Birmingham (UAB). The funding will support a research project to investigate the role of a novel histone modification, H3T32 O-GlcNAc, in endothelial cell dysfunction and atherosclerosis. The 5-year project aims to elucidate the epigenetic features of this histone modification under...
- The University of South Florida was awarded a $2,074,842 Project Grant by the National Heart, Lung, and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) to investigate how post-translational modifications of the CaMKII protein during chronic diabetes impact endothelial small-conductance calcium-activated potassium (SK) channel activity, coronary microvascular function, and myocardial blood flow. The overall goal is to expand scientific understanding of the mechanisms underlying...
- The University of Alabama at Birmingham received a $561,392 Project Grant award from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of RNA methylation in the progression of cardiac fibrosis and heart failure. The project aims to study the contribution of the RAPGEF5 gene and the METTL3 enzyme to the regulation of beta-catenin nuclear translocation, a key mechanism underlying cardiac fibrosis. The research...
- The University of Alabama at Birmingham (UAB) received a $222,750 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to develop a clinical decision support questionnaire to identify barriers to blood pressure control. The project aims to address the high rates of uncontrolled hypertension in the U.S., which is a leading cause of morbidity, mortality, and substantial healthcare costs. The award, with a performance period from July...
- This Project Grant award, valued at $249,000.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program. The grant supports a research project at the University of Alabama at Birmingham (UAB) titled "Early Life Stress and Cardiovascular Disease Risk: Identifying the Role of Microbial Metabolites." The project aims to investigate how early life stress affects the gut microbiome and related...
- This $702,534 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Texas A&M Engineering Experiment Station (Tees) to develop an integrated super-resolution cardiac magnetic resonance imaging-deep learning (CMR-DL) technology. The goal is to isolate and quantify the contributions of passive and active mechanisms to impaired left ventricular relaxation, a key driver of left ventricular diastolic dysfunction...
- This federal Project Grant award of $740,037, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the regulation of angiogenesis (blood vessel formation) by cardiac fibroblasts following myocardial infarction. The key objectives are to investigate the temporal and spatial expression of pro- and anti-angiogenic factors secreted by cardiac fibroblasts to support cardiac repair and increase vascular...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $637,126 to the Trustees of Indiana University, doing business as Indiana University Indianapolis, to conduct research on the regulatory mechanisms of neovascularization, cardiomyocyte survival, and endothelial cell-cardiomyocyte crosstalk in myocardial infarction. The project aims to elucidate the roles of novel endothelial cell- and cardiomyocyte-specific...
- This federal Project Grant award of $169,020.00 was provided by the National Heart Lung and Blood Institute (NHLBI), which operates under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pennsylvania investigating the impact of obesity and diabetes on coronary microvascular defects in heart failure with preserved ejection fraction (HFpEF). The research will use an animal model of HFpEF to compare the temporal progression...
The University of Alabama at Birmingham (UAB) received a $637,732 project grant from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on improving the cardiac microenvironment as a novel strategy against diabetic ischemic heart failure. The project aims to leverage insights from cellular secretome research to transform treatment strategies for diabetic ischemic heart failure. Specifically, the research will investigate how the downregulation of the cardioprotective molecule CTRP9 in diabetes adversely impacts the properties and cardioprotective effects of small extracellular vesicles. The project will explore an engineered approach to modify these extracellular vesicles to effectively overcome the challenges of rescuing the compromised microenvironment in diabetic ischemic heart failure. The award period runs from September 16, 2025 to June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $637.7k | 9/16/25 |