Project Grant R01HL172993
- This $416,849 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to validate a peptide probe called Transthyretin Amyloid Detection 1 (TAD1) as a blood biomarker for detecting cardiac amyloidosis in minority populations. The award was made to the University of Texas Southwestern Medical Center to determine the diagnostic value of the TAD1 assay in a cohort of over 600 Black and Hispanic heart failure patients who have been...
- This Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research, provides $815,229 to The University of Texas Southwestern Medical Center to conduct advanced research on cardiovascular disease susceptibility and resilience in Black Americans. The key objectives are to: 1) Identify proteins and protein networks associated with clinical and subclinical cardiac dysfunction, 2) Pinpoint proteins and networks linked to...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $235,608 to the University of Texas Southwestern Medical Center to conduct research on the impact of defective lipoylation on cardiac function and failure. The research aims to characterize the underlying mechanisms of cardiometabolic disorders using an inborn error of metabolism condition caused by LIPT1 gene deficiency as a model system. Key objectives include...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $611,014 to the University of Connecticut Health Center to develop and optimize adeno-associated virus (AAV) therapies for treating cardiac disorders caused by pathogenic variants in the TNNT2 gene. The project aims to engineer next-generation AAVs capable of delivering wild-type TNNT2 and selectively suppressing mutant TNNT2 mRNA in cardiomyocytes. This...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $810,875 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of the University of Pennsylvania (UEI GM1XX56LEP58) for the period of June 15, 2025 to March 31, 2029. The project aims to develop two complementary chimeric antigen receptor (CAR) T cell strategies to selectively deplete B cells that produce autoantibodies against ADAMTS13, a key regulator of platelet activation. This research...
- This federal Project Grant award, totaling $249,000.00, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Texas Southwestern Medical Center in Dallas, TX. The grant supports research to better understand the molecular determinants of atrial fibrillation (AF), a common and serious heart rhythm disorder. The research aims to investigate how the transcription factor TBX5 and the chromatin remodeling protein CHD4...
- This Project Grant award of $520,483 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at The University of Texas Southwestern Medical Center to develop adeno-associated virus (AAV)-based gene therapy tools for efficient delivery of therapeutic cargos to the atrioventricular node (AVN) of the cardiac conduction system. The long-term goal is to devise new therapeutic approaches for cardiac dysrhythmias. The key objectives are to...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $164,127 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Texas Health Science Center at Houston (UTHealth) to develop an artificial intelligence-based facial recognition tool for screening and early detection of heritable thoracic aortic disease (HTAD). The project aims to leverage facial image data from the Montalcino Aortic Consortium's patient registry to build a...
- This $702,534 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Texas A&M Engineering Experiment Station (Tees) to develop an integrated super-resolution cardiac magnetic resonance imaging-deep learning (CMR-DL) technology. The goal is to isolate and quantify the contributions of passive and active mechanisms to impaired left ventricular relaxation, a key driver of left ventricular diastolic dysfunction...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,513,201 in funding to The Trustees of the University of Pennsylvania to research excess cardiovascular inflammation in tuberculosis (TB) and HIV. The overarching hypothesis is that TB promotes pulmonary inflammation leading to subclinical vascular pathology, increasing the risk of major cardiovascular events in TB survivors. The research will investigate...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $691,556 to The University of Texas Southwestern Medical Center (UT Southwestern) to determine the presence of amyloid in the blood and early cardiac amyloid infiltration in individuals of African ancestry who carry the V122I transthyretin (TTR) allele. The key objectives are to: 1) Assess the association between V122I TTR carrier status and circulating TTR amyloid aggregates, including the impact of TTR stabilizing therapy; and 2) Evaluate the association between V122I TTR carrier status and cardiac amyloid infiltration using I-124E positron emission tomography (PET) imaging. This research aims to develop screening techniques to detect early-stage hereditary cardiac amyloidosis in this high-risk population, enabling timely diagnosis and treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $691.6k | 8/18/25 |