The National Heart, Lung, and Blood Institute (NHLBI) awarded a $163,080 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Ann & Robert H Lurie Children's Hospital of Chicago. The grant, effective September 1, 2024 through August 31, 2029, will support research to understand the regulatory T cell response in children with severe viral pneumonia. The project aims to determine if juvenile regulatory T cells have impaired reparative functions during severe viral pneumonia, assess how the lung microenvironment affects regulatory T cell recovery functions, and identify regulatory T cell transcriptional signatures associated with outcomes in pediatric patients. This research is expected to lay the foundation for developing novel therapeutic strategies to hasten recovery and improve long-term respiratory health in children with severe viral pneumonia.
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