Project Grant R01HL170152
- This $738,472 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), to The Trustees of the University of Pennsylvania. The grant supports a research project titled "CARDIOVASCULAR RISK PREDICTION AND REDUCTION IN MEN WITH PROSTATE CANCER". The objective is to develop accurate cardiovascular disease (CVD) risk prediction models for men with prostate cancer, as existing tools...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $165,672 to New York University School of Medicine to conduct research aimed at increasing heart transplant (HT) volume in the United States. The key objectives are to: Investigate the impact of donor risk factors, such as coronary artery disease, left ventricular dysfunction, and older age, on post-HT outcomes using European and U.S. registry data. This...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $174,420 to The Trustees of the University of Pennsylvania to conduct research aimed at improving lung transplantation outcomes. The key objectives are to investigate the impact of centralizing deceased organ donor management at specialized Donor Care Units (DCUs) and assess the consequences for diverse stakeholders in the national donation and transplantation...
- The University of Utah received a $782,289 project grant award from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to develop machine learning models that incorporate donor lung CT images to predict the risk of severe primary graft dysfunction (PGD) in lung transplant recipients. The project aims to leverage a multi-center cohort of lung transplant data to build improved predictive models that fuse donor and recipient clinical data with...
- This $1,137,498.00 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research to investigate the regulatory mechanisms involved in cardiac maturation. The primary awardee, The Trustees of the University of Pennsylvania, will conduct this work between April 1, 2025 and March 31, 2032. The research aims to address three key questions: 1) whether naturally-occurring variants in human cardiomyocyte genomic...
- This $153,117 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of the recipient's independent research career as an academic hematopathology physician-scientist. The key objectives are to study hematopoietic stem and progenitor cell (HSPC) crosstalk and transplantation, with the overarching goal of improving HSPC transplantation outcomes. The award period runs from August 1, 2025 to July 31,...
- This $726,205 federal Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the development and validation of a new super-resolution intravascular ultrasound (SR-IVUS) technology. The goal is to enable effective imaging of the coronary vasa vasorum network and thin fibrous cap of vulnerable atherosclerotic plaques to better assess plaque vulnerability and prevent acute coronary syndromes. The project involves creating an...
- This federal Project Grant award, with a total funding amount of $304,415.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The goal of this 1-year project is to develop a software solution that uses artificial intelligence and image analytics to improve cardiovascular risk prediction from screening CT calcium score (CTCS) images. The project team, which includes engineers and clinicians from...
- This $240,552 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a research project titled "Unraveling the Cell Networks in Bone Marrow Through Transcriptomic and Epigenetic Profiling" at the University of Pennsylvania. The project aims to generate a comprehensive single-cell transcriptomic and regulomic map of human bone marrow cells and experimentally establish the mesenchymal cell hierarchy in human bone....
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at New York University School of Medicine to investigate the use of HLA eplet mismatches (EMM) as a biomarker for immunologic risk in heart transplant recipients. The $819,532 award aims to leverage existing datasets and patient cohorts to model the association between EMM and immunoreactivity, which could help guide personalized immunosuppression...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $705,063 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, for the project "Personalized Risk Prediction and Mechanistic Profiling of Cardiac Allograft Vasculopathy". The award period runs from Aug 15, 2025 to May 31, 2029. The project aims to develop advanced digital pathology techniques, including computer-aided image analysis and spatial-molecular profiling, to improve risk assessment and mechanistic understanding of cardiac allograft vasculopathy (CAV) - a leading cause of transplanted heart failure and loss. By leveraging these novel digital analysis methods, the research seeks to identify new "morphologic biomarkers" that can quantify microscopic changes in the cardiac microarchitecture, providing clinicians with more personalized, early-stage detection capabilities for CAV beyond the current focus on large-vessel manifestations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $705.1k | 8/11/25 |