The University of North Carolina at Chapel Hill received a $751,747 Project Grant award under the National Heart, Lung, and Blood Institute's (NHLBI) Cardiovascular Diseases Research program (CFDA 93.837) to study the role of the enzyme CARM1 in regulating cardiomyocyte (heart muscle cell) maturation. The research aims to define key factors and signaling pathways that control cardiomyocyte structural, functional, and electrophysiological maturation during the neonatal stage. Specifically, the project will investigate how CARM1-mediated transcriptional and post-transcriptional regulation impacts multiple aspects of cardiomyocyte maturation. This new knowledge is expected to guide the development of strategies to enhance cardiomyocyte maturation for regenerative medicine applications. The award period runs from January 1, 2025 through November 30, 2028.
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