Project Grant R01HL163419

Award Date 8/15/24
Completion Date 5/31/29
Dollars Obligated $1.3M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Louisville, KY 40202, USA
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This Cooperative Agreement award of $2,529,292.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a randomized clinical trial to evaluate two interventions for improving mobility in patients with peripheral artery disease (PAD) who have undergone lower extremity revascularization. The primary aims are to determine if: 1) home-based exercise combined with revascularization improves 6-minute walk distance more than revascularization alone,...
This federal Project Grant award, with a total funding amount of $153,252, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award will support a 3-year research program focused on elucidating the molecular mechanisms and clinical significance of a specific macrophage population (SPP1+ macrophages) in peripheral arterial disease (PAD). The primary objectives are to determine if SPP1+ macrophages inhibit...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $687,517 to the University of Alabama at Birmingham to investigate the role of the protein Leiomodin1 (LMOD1) in the formation of mature blood vessels, which is critical for treating peripheral artery disease (PAD). The research aims to elucidate the mechanistic pathway by which reduced LMOD1 leads to impaired blood vessel maturation, determine if this...
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This Project Grant award of $1,306,060.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a pilot clinical trial to investigate the efficacy of carnosine supplementation for improving lower extremity function in patients with peripheral arterial disease (PAD). The key objectives are to:

  1. Treat PAD patients with carnosine and examine if it improves lower extremity function.
  2. Perform mechanistic studies to elucidate how carnosine improves muscle function.
  3. Follow patients to determine if carnosine has durable effects.

The University of Louisville is the primary awardee, and they have subcontracted with the University of Cincinnati to provide statistical analysis support for the Phase I/II clinical study. The pilot trial aims to establish carnosine as a low-cost therapeutic intervention for PAD, with the data serving as a rationale for a larger definitive Phase III clinical trial.

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