The University of Pittsburgh was awarded a $761,042 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) from the National Heart, Lung, and Blood Institute (NHLBI) to conduct research on the mechanisms driving medial arterial calcification (MAC) in peripheral artery disease (PAD). The project aims to investigate how the DNA damage response and reduced CD73-mediated adenosine production contribute to the upregulation of osteogenic transcriptional programs in smooth muscle cells, leading to MAC pathogenesis in PAD. The grant period runs from March 5, 2025 to December 31, 2028. The research conducted under this award is expected to identify novel, druggable pathways for treating MAC in PAD patients.
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