Project Grant R01HG014255
Award Date 9/20/25
Completion Date 8/31/29
Dollars Obligated $805K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Storrs, CT 06269, USA
Similar Awards
- The University of Washington was awarded a $2,217,249 federal Project Grant from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) on September 10, 2025 to develop advanced sequence-to-function (S2F) deep learning models that can accurately predict the subtle gene expression consequences arising from natural genetic variations. The project aims to address two key challenges: 1) current models struggle to generalize across diverse genotypes found in personal...
- The National Human Genome Research Institute (NHGRI), through the Human Genome Research program (CFDA 93.172), awarded a $444,125 Project Grant to the Rector & Visitors of the University of Virginia (UVA) to develop computational models that accurately quantify open chromatin bias and TN5 intrinsic cleavage bias in both bulk and single-cell Cleavage Under Targets & Tagmentation (CUT & TAG) data. The models will characterize how these biases affect the detection of histone...
- The National Science Foundation (NSF) awarded a $200,000 Project Grant under the Biological Sciences (CFDA 47.074) Federal Grant Program to Cornell University to develop tools and infrastructure for improving the efficiency of whole genome sequencing (WGS) data analysis. The project aims to optimize the Genotype Representation Graph (GRG) data structure for modern parallel computing architectures, particularly GPUs, to handle the dynamic nature of genomic computations. Additionally, the...
- This $836,598 Project Grant, awarded by the National Science Foundation (NSF) under the Biological Sciences Federal Grant Program (CFDA 47.074), supports research to develop tools for sequencing expanded genetic alphabets and studying how natural biological systems interact with these unnatural DNA letters. The research aims to improve the generalizability and accuracy of next-generation sequencing for unnatural base pairs, develop new methods for measuring polymerase replication fidelity, and...
- The National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) awarded Panluminate Inc., a woman-owned small business in Connecticut, a $404,117 project grant on June 15, 2025. The purpose of the grant is to develop CHROMEX30, a novel variant of Panluminate's proprietary Pan-Expansion Microscopy (PAN-EXM) technology, to enable high-resolution (~10 nm) nanoscale imaging of genetic organization and disease phenotypes. The key project goals are to: (1) develop, optimize, and...
- The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
- This $993,446 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical cooperative programs of genes and genomic elements. The goal is to produce computational tools and workflows that can identify and rank functionally disease-critical...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $394,857 to the University of Nebraska to develop a system to protect and concentrate large DNA molecules for genome analysis. The project aims to: Develop an inverted insert to protect DNA during cell lysis. Develop a roadblock to concentrate chromosomal DNA. The goal is to create a method to protect and concentrate large DNA molecules...
- The National Science Foundation (NSF) awarded a $597,893 Project Grant under the Computer and Information Science and Engineering (CFDA 47.070) program to the University of Connecticut (UConn). This 3-year grant, starting on May 1, 2024, is dedicated to developing novel algorithms and computational methods that integrate genomics, pathology, and other multimodal data to build precise disease prediction models. The project aims to advance the state-of-the-art in integrating diverse molecular data...
- The National Human Genome Research Institute (NHGRI) awarded a $1,711,422 Project Grant (CFDA 93.172 - Human Genome Research) to the New York Genome Center, Inc. (NYGC) on September 23, 2024. The goal of this project is to develop a suite of privacy-preserving tools for transcriptomic data analysis, including methods for quantifying bulk and single-cell gene expression, as well as performing expression quantitative trait locus (eQTL) mapping on encrypted genotypes. This will enable large-scale...