Project Grant R01HG004456

The Alida Biosciences Inc. was awarded a $765,105 Project Grant from the National Institutes of Health National Human Genome Research Institute under the Human Genome Research federal grant program (CFDA 93.172) on August 17, 2021 to complete work by February 28, 2022. The grant funds the development of a new approach to analyze RNA modifications across entire transcriptomes in a multiplexed reaction at near single-base resolution. Currently available methods either lack sequence context or...

Federal Project Grant Award Summary Xgenomes Corp. received a $795,198 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded June 1, 2025, with a completion date of February 28, 2027. The grant funds development of a novel epigenetic analysis method for sequencing DNA methylation modifications across the genome using single-molecule detection of oligonucleotide binding kinetics. This technology addresses critical...

Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $315,060 Project Grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded June 10, 2025, with completion targeted for May 31, 2026. The grant supports the development of a cell-type-specific atlas of transcription factor (TF)-element connectivity across human tissues by integrating single-cell and single-nucleus Assay for...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...

Federal Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded Columbia University's Health Sciences Division a Project Grant of $3.24M under the Human Genome Research program (CFDA 93.172) for research on computational and experimental approaches to decode domain-specific protein-RNA interactions. The four-year project, initiated April 1, 2026 and concluding March 31, 2030, addresses a critical gap in understanding how RNA-binding proteins (RBPs) regulate gene...

The University of Pennsylvania received a $1,529,885 Cooperative Agreement from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) to develop novel statistical and computational methods for analyzing developmental gene expression data from the DGTEX (Developmental Genotype-Tissue Expression) and NHP DGTEX projects. The overarching goal is to create tools for effective analysis of age-dependent gene expression functions across different...

The U.S. National Human Genome Research Institute (NHGRI) awarded a $1,696,968 Cooperative Agreement grant (CFDA 93.172 - Human Genome Research) to the University of California, Santa Cruz to develop novel computational methods and software tools for analyzing pangenomic data, with a focus on improving the accuracy and efficiency of variant calling and genotyping, particularly for complex structural variants. The grant, titled "Tools for Comprehensive Variant Characterization Using the...

Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded The Children's Hospital of Philadelphia Research Institute a Project Grant totaling $863,248 (award date: February 1, 2026; completion date: January 31, 2030) under the Human Genome Research program (CFDA 93.172) to investigate three-dimensional (3D) chromatin architectural dynamics at ultra-high resolution. The research deliverables include: (1) development and application of ultra-high resolution...

Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded University of California Santa Cruz $633,116 on September 26, 2025, under the Human Genome Research program (CFDA 93.172) to advance comparative genomics through three integrated research objectives. The project, which extends through June 30, 2029, will deliver scalable computational tools and methodologies for analyzing thousands of vertebrate genomes. Primary deliverables include: (1) an automated...

Federal Grant Award Summary: SPINSEQ Project Electronic Biosciences, Inc. received a Phase I Small Business Innovation Research (SBIR) Project Grant of $383,482 from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded on June 6, 2025, with a completion date of May 31, 2027. The company is developing SPINSEQ, an innovative RNA sequencing platform designed to deliver precise and accurate transcriptomic analysis while preserving RNA...