Project Grant R01HD120978

Federal Grant Award Summary

The National Institute of Child Health and Human Development (NICHD) awarded a $727,070 Project Grant to Weill Medical College of Cornell University, with an award date of June 2, 2026, and completion date of May 31, 2031, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project, titled "Deriving Real World Insights to Inform Trials for Pregnant Individuals Using Electronic Health Records and Machine Learning," will leverage electronic health records and machine learning analytics to generate clinical evidence on medication safety and efficacy for pregnant women—a population historically excluded from clinical trials despite nearly universal medication use during pregnancy.

The research will address critical evidence gaps in three key therapeutic areas: COVID-19 prevention and treatment in pregnancy, including vaccines and antivirals; diabetes and obesity management using GLP-1 agonists and SGLT2 inhibitors; and perinatal mood and anxiety disorder treatment with selective serotonin reuptake inhibitors. By extracting real-world clinical data from existing health records, this project will inform the design and conduct of future clinical trials for pregnant individuals, ultimately enabling clinicians and patients to make evidence-based treatment decisions for conditions associated with increased risk of adverse pregnancy outcomes.