Project Grant R01HD116587

Award Date 8/6/24
Completion Date 5/31/29
Dollars Obligated $637K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Baton Rouge, LA 70808, USA
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This Project Grant award in the amount of $710,899.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), to The Washington University in St. Louis. The goal of this research project is to delineate the short and long-term neurocognitive impact of late-childhood iron deficiency anemia (IDA) in young females. Specifically, the project will evaluate cognitive function and brain structure/connectivity...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $576,296 Project Grant to the University of California, Los Angeles (UCLA) to conduct research on the mechanisms by which iron deficiency can exacerbate inflammatory tissue injury. The research aims to define how iron deficiency potentiates inflammation, worsens inflammatory lung and kidney injury, and modifies...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $231,708 to support research on the implications of iron homeostasis and ferroptosis in early pregnancy and endometriosis. The research aims to investigate how dysregulation of the iron export protein SLC40A1 (ferroportin) contributes to elevated oxidative stress and compromised decidualization...
This $2,252,730 Project Grant award from the National Institute on Minority Health and Health Disparities (CFDA 93.307) will fund research to measure the long-term health outcomes, health equity, and economic impacts of four key interventions to address food and nutrition insecurity in the U.S. The research team at the University of Chicago will use their NIH-funded microsimulation model to analyze the effects of interventions such as expanding the USDA Gus Schumacher Nutrition Incentive Program...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $225,000 to investigate the role of the protein α-synuclein in regulating the erythroid iron restriction response. The research aims to elucidate how α-synuclein and the neurotransmitter dopamine modulate erythropoiesis during iron deficiency, which can lead to iron deficiency anemia....
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is funded under the Cardiovascular Diseases Research program (CFDA 93.837). The $213,284 award to the Rector & Visitors of the University of Virginia (UVA) supports research to decipher the molecular mechanisms by which systemic iron homeostasis regulates endothelial function and hemoglobin alpha (HBA) expression in the microvasculature. The central hypothesis...
This Project Grant award, valued at $708,794.00 and granted by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to identify optimal dietary patterns for postpartum cardiovascular disease prevention. The research will establish the role of longitudinal dietary patterns in the development of cardiovascular disease and risk factors from periconception to 10 years postpartum, and explore how social determinants of health...
This $657,757.00 Project Grant awarded by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to reduce nutrition insecurity and malnutrition among adolescents in low- and middle-income countries. The grant funding will support an innovative combination of participatory systems thinking methods, quantitative data, and modeling to characterize food environments and understand how individual, household, and...
This federal Project Grant award for $1,332,733.00, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the impact of preconception lifestyle factors, such as physical activity, diet, and sleep, on pregnancy outcomes. The award recipient, The Trustees of the University of Pennsylvania, will leverage the linkage between the National Health and...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $412,500.00 in funding to the University of South Florida (USF) to conduct a longitudinal study of gut dysbiosis in anemic preterm infants. The goal is to determine the hematocrit threshold associated with gut microbiome changes and how anemia development influences the microbiome and host interactions...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $636,890 to the Pennington Biomedical Research Center to determine dietary iron requirements in a representative sample of U.S. adults. The key objectives are to: 1) Quantify iron losses and 2) Determine iron bioavailability from three different mixed diets typically consumed in the U.S. The study will explore factors affecting iron loss and bioavailability, and integrate the findings with the All of Us research database to inform updates to the current Dietary Reference Intakes (DRIs) for iron, ensuring they accurately reflect the needs of the diverse U.S. population. This award, with a performance period from August 2024 to May 2029, leverages the infrastructure and participant pool of the larger Nutrition for Precision Health (NPH) trial powered by the All of Us Research Program.

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