Project Grant R01GM166753
- The National Institute of General Medical Sciences awarded The Regents of the University of California at Riverside $923,313 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support cellular programming research using plant photoreceptor signaling models. The project interrogates the function of subnuclear membraneless organelles called photobodies in cell signaling and nuclear gene regulation, and the regulatory mechanisms of organellar gene...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $1.624736 million under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026. The award funds research into morphological reprogramming of the endoplasmic reticulum by cellular mucins. The project tests the hypothesis that transmembrane mucins act as membrane curvature generators on the luminal face of the endoplasmic...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded the University of California, Davis $390,881 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to decode the mechanisms and regulatory networks of plant U-box/ring ubiquitin ligase complexes under biotic stress. The research unravels the molecular mechanisms, structural dynamics, and regulatory networks of two highly conserved classes of E3 ligases—plant U-box (PUB) ligases and a specific...
- The National Institute of General Medical Sciences awarded the University of California Irvine $365,267 on July 1, 2026, to investigate the structural and biochemical basis of NLRP3-mediated innate immune signaling under the Biomedical Research and Research Training program (CFDA 93.859). The project examines how the innate immune receptor NLRP3 recognizes and processes oxidized mitochondrial DNA (ox-mtDNA) to trigger inflammasome assembly. Aberrant NLRP3 activation contributes to chronic...
- The National Institute of General Medical Sciences awarded the University of California, Davis $675,667 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemoenzymatic strategies for synthesizing glycans and glycoconjugates. The research program focuses on two major directions: developing innovative chemoenzymatic methods for synthesizing complex bacterial surface glycans, including those with multiple polysaccharide repeating units applicable...
- The National Institute of General Medical Sciences awarded the University of California, Davis $432,417 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how linear and nonlinear mechanical forces in the extracellular matrix regulate cell metabolism through mechanotransduction pathways. The research uses induced pluripotent stem cells in both single-cell and organoid cultures within three-dimensional polymeric hydrogel systems to...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Institute of General Medical Sciences awarded $441,375 to The Regents of the University of California, doing business as University of California, Berkeley, on September 1, 2026, under the R35 (MIRA) program (CFDA 93.859, Biomedical Research and Research Training). The award funds a five-year project investigating how tissues integrate immune-cell derived signals to regulate inflammation, repair, and homeostasis. The research pursues three interconnected directions: dissecting how...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Washington University a $2.14 million Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to support a four-year research initiative titled "Rhythms of Resistance: Unraveling the Impact of Natural Circadian Variation on Immunity." Effective from September 1, 2025, through August 31, 2029, this award funds fundamental biomedical research...
The National Institute of General Medical Sciences (NIGMS) awarded the University of California, Davis $521,604 on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research into spatially coordinated signaling directed by sensory organelles in innate immunity. The research investigates how plant chloroplasts function as sensory organelles that detect pathogens and orchestrate immune responses. Specifically, the work examines morphological changes in chloroplasts during effector-triggered immunity, including stromule formation (stroma-filled tubules) and perinuclear chloroplast clustering that promotes cell death and limits infection. The project identifies and characterizes proteins essential for stromule formation and signaling, including a previously identified component (KIS1) and newly discovered plasma membrane and chloroplast calcium channels involved in membrane contact sites. The research will elucidate the spatial and temporal coordination of calcium and hydrogen peroxide signaling during immunity through dual calcium and hydrogen peroxide sensors. Performance occurs at UC Davis in Davis, California, with a period of performance running from August 3, 2026, through March 31, 2030. The award is a Project Grant, the standard R01 assistance type under the NIGMS program, which supports investigator-initiated basic research that increases understanding of biological processes and provides foundational knowledge for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $521.6k | 8/3/26 |