Project Grant R01GM165993
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $433,125 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop imaging-based molecular recording methods that reconstruct the signaling history of individual cells during development. The funded research extends a signal-recording approach that uses regulated CRISPR base editors to generate mutations in engineered genomic target sites at rates...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $406,432 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply mass spectrometry-based chemoproteomic technologies that identify functional and redox-sensitive cysteine residues in proteins, with the goal of discovering therapeutically relevant cysteines to support covalent drug development. The research program focuses on three main...
- The National Institute of General Medical Sciences awarded University of California, Los Angeles $363,570 on March 15, 2026, to develop probabilistic methods for integrating imaging and genomic data to reconstruct three-dimensional genome structures from individual imaged nuclei. The project addresses limitations in current 3D genome structure models derived solely from genomic data, which lack precise physical dimensions, fail to capture nuclear morphologies accurately, and are constrained by...
- The National Institute of General Medical Sciences, a bureau of the National Institutes of Health within the Department of Health and Human Services, awarded $301,936 to the University of California, Los Angeles on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds data-science-guided study and design of phosphoranyl radical-mediated reactions for the discovery of novel pharmaceutical compounds. The research builds a comprehensive,...
- The National Institute of General Medical Sciences awarded the University of Southern California $456,500 on September 1, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to decode and remotely reprogram cellular signaling networks. Work will extend through August 31, 2031, performed in Los Angeles, California. The recipient will develop multiplexed single-fluorophore biosensors to simultaneously visualize multiple signaling activities—including tyrosine kinase...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $420,981 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop engineered enzymatic catalysts for asymmetric hydrogen atom transfer reactions in synthetic chemistry. The research integrates organic chemistry, protein engineering, bioinorganic chemistry, and computational modeling to design and evolve biocatalysts that enable...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded $433,125 to the University of California, Los Angeles on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research mapping the mechanome—the systems-level set of genes, proteins, and pathways that regulate cellular mechanical behaviors. The Rowat Lab will conduct two lines of research to identify novel mediators of cell mechanical...
- The National Institute of General Medical Sciences awarded $433,125 to the University of California, Los Angeles on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing). Andrew Holbrook, a biostatistician at UCLA, will develop AI-accelerated inference strategies and open-source software for Bayesian hierarchical models applied to high-impact biostatistical problems. The work addresses a computational bottleneck in biomedical research:...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $551,000 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop function-selective modulators of multifunctional hub proteins. The research expands two programs: developing molecular glues to stabilize native protein-protein interactions and establishing technologies to study dynamic protein-interaction networks. The work...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Irvine a $1.89 million Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through August 31, 2029. The research initiative focuses on developing molecular lanterns—ultra-small ribonucleic acid (RNA) tags that assemble split luciferases—to enable real-time visualization and tracking of multiple RNA transcripts...
The National Institute of General Medical Sciences awarded the University of California, Los Angeles $1,221,553 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an imaging method for mapping functional G protein-coupled receptor (GPCR) signaling in tissue sections at subcellular resolution with G protein specificity. The project addresses the need to understand how GPCR signaling is functionally organized within tissues across multiple spatial scales, from nanoscale synapses to tissue microanatomy. Existing spatial-omics methods are insufficient because GPCR signaling is regulated by complex factors including post-translational modifications, trafficking, membrane lipid composition, and protein-protein interactions. UCLA's approach applies GPCR-selective agonists to unfixed tissue sections while recording G protein subtype activation at the molecular level, followed by tissue fixation and fluorescence imaging of activated G protein subunits. The team has demonstrated feasibility by imaging G protein activation across entire mouse brain sections in response to Gi/o-coupled receptor agonists and will perform subsequent development steps to establish the method as widely applicable for studying GPCR signaling in tissue sections with preserved microanatomy. Performance occurs in Los Angeles, California. The award period runs through August 31, 2030. UCLA operates this work through its Office of Research Administration.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/24/26 |