Project Grant R01GM162731
- The National Institute of General Medical Sciences awarded Oklahoma State University $373,960 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on genome evolution and design in small, single-stranded DNA phages (Microviridae). The award is structured as a Project Grant with a period of performance running through August 31, 2031. Work is performed in Oklahoma City, Oklahoma. The National Institute of General Medical Sciences...
- The National Science Foundation Division of Chemistry awarded the University of Oklahoma $650,000 on August 1, 2026, through the Mathematical and Physical Sciences program (CFDA 47.049) for research on sulfur-mediated strategies for stereocontrolled glycosylation. The project, led by Dr. Indrajeet Sharma, will develop sustainable synthetic methods for carbohydrate-based molecules used in medicines, vaccines, and biological systems. Current methods require harsh acids, expensive precious...
- The National Institute of General Medical Sciences awarded $548,084 to the University of North Texas Research and Innovation Division on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop ruthenium(II)-catalyzed enantioselective functionalization of arene and alkene derivatives for asymmetric synthesis of natural products and complex organic molecules. The research targets enantioselective functionalization of ortho- and meta-aryl C-H bonds...
- The National Institute of General Medical Sciences awarded the University of Rochester $448,196 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop synthetic tools for constructing carbon-nitrogen bonds using N-aryl and N-alkenyl nitrogen intermediates. The research targets the synthesis of nitrogen heterocycles, which are critical structural components in pharmaceuticals and natural products. The project will develop catalytic methods to...
- The National Institute of General Medical Sciences awarded the University of Oklahoma $2,548,979 on May 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to establish the Oklahoma Center of Immunoengineering (OCIE). OCIE consolidates immunoengineering and omics data science research infrastructure across Oklahoma by establishing two research cores: the Immunomodulation Technology Core and the Omics Data Science Core. These cores provide facilities,...
- The National Institute of General Medical Sciences awarded the University of Delaware $479,532 on August 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemical methods for the synthesis of complex nitrogen-containing small molecules essential to modern pharmaceuticals. The award funds research on electrophilic nitrogen chemistry to create new synthetic methods that rapidly prepare structurally and topologically complex organic molecules. The...
- The National Institute of General Medical Sciences awarded the University of Oregon $398,464 on March 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop responsive and targeted modulation of reactive sulfur species. Over the five-year period of performance ending December 31, 2030, the recipient will develop innovative chemical approaches to manipulate and understand hydrogen sulfide (H2S) and reactive sulfur species (RSS) in biological systems. The...
- The National Institute of General Medical Sciences awarded Oregon State University $1.2 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate novel regulatory mechanisms that control secondary metabolite biosynthesis in microorganisms. The funded research addresses the challenge of discovering and expressing biosynthetic gene clusters (BGCs) that produce bioactive natural products for drug development. The project tests two primary...
- The National Institute of General Medical Sciences, a component of the National Institutes of Health, awarded The University of Chicago $590,711 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports development of new synthetic methods to accelerate preparation of diverse analogues for medicinal chemistry studies. Over the five-year performance period ending June 30, 2031, the research addresses carbon-carbon...
- The National Institute of General Medical Sciences awarded the University of Houston System $1.399 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a technological platform for covalent protein biologics that combine rapid tissue penetration with extended target engagement. The research will generate an accelerated platform to produce covalent and covalent-reversible biologic drugs, addressing a fundamental limitation in protein...
The National Institute of General Medical Sciences awarded the University of Oklahoma a Project Grant of $360,157 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply sulfenylcarbenes and sulfenylnitrenes as reagents for site-selective chemical transformations in drug discovery. The research addresses the slowdown in pharmaceutical development by expanding chemical space through scaffold hopping—transforming established drug frameworks into new structures. The project leverages sulfur's metallomimetic properties to stabilize reactive intermediates (carbenes and nitrenes) and direct highly selective reactions under mild, metal-free conditions. Aim 1 develops sulfenylcarbenes as one-carbon insertion reagents bearing diverse functional groups for late-stage diversification of aromatic heterocycles and metal-free peptide stapling under aqueous conditions. Aim 2 investigates sulfenylnitrenes for single nitrogen-atom transfer reactions. This approach minimizes environmental impacts associated with metal-based transformations while enabling precise chemoselective modifications of complex molecules. The University of Oklahoma, performing through its Office of Research Administration in Norman, Oklahoma, is the recipient. The award period runs from September 1, 2026, through August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/18/26 | ||
| Not listed | $360.2k | 8/17/26 |