Project Grant R01GM162376
- The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $462,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance spatial imaging frameworks that reveal how non-coding RNAs organize within the nucleus across developmental and environmental contexts. The research establishes three interconnected themes. Theme 1 extends RNA MERFISH to profile small non-coding RNAs by incorporating enzymatic...
- The National Institute of General Medical Sciences awarded $462,000 to Icahn School of Medicine at Mount Sinai on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing) to support research into the molecular mechanisms of gating and selectivity in the MSCs and MRS2 superfamilies of ion channels. The research combines biochemical, biophysical, and electrophysiological approaches to understand two ion channel superfamilies: mechanosensitive...
- The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $420,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and deploy genetic interaction mapping tools in bacteria. The project will construct a comprehensive genetic interaction network in Escherichia coli by developing a barcoded CRISPR strategy to systematically profile all pairwise genetic interactions (approximately 10 million) and...
- The National Institute of Child Health and Human Development awarded Icahn School of Medicine at Mount Sinai $464,750 on June 2, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865 / 93.HDR) to investigate planar cell polarity function of the Wnt co-receptor LRP5/6-Arrow in child development and organogenesis. The funded research examines the role of Arrow-LRP5/6 in Wnt/planar cell polarity (PCP) signaling and the regulation of signaling specificity...
- The National Institute of General Medical Sciences (NIGMS) at the Department of Health and Human Services awarded $420,093 to the Regents of the University of Michigan on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds a five-year investigation into how cells self-organize to sculpt tissue interfaces and generate the characteristic curvatures that shape organ architecture and function. The research takes a systems-level approach to...
- The National Institute of General Medical Sciences awarded The Salk Institute for Biological Studies $515,625 on June 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate fundamental mechanisms of cytoskeletal dynamics and transport, with focus on how connector proteins link molecular motors to cellular cargo and facilitate transport along microtubule tracks. The research examines two primary areas: the role of spectraplakin proteins, which link...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Icahn School of Medicine at Mount Sinai $100,228 on November 16, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate mechanosensation in fibro-adipogenic progenitors during skeletal muscle regeneration. The project will elucidate how muscle-resident mesenchymal stromal cells sense mechanical changes in their environment through...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $2.2 million in a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on August 5, 2026, to support research on morphogenesis and maintenance of the epidermis. The funded research explores how specific molecules function in patterning, morphogenesis, and maintenance of skin using the nematode C. elegans as a model system. The program combines molecular genetics, advanced imaging,...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Icahn School of Medicine at Mount Sinai $551,321 on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the cellular and molecular mechanisms governing dermal condensate formation during embryonic hair follicle development. The research explores how axon guidance signaling regulates the migration and clustering of dermal papilla cell progenitors...
- The National Institute of General Medical Sciences awarded $471,690 to Weill Medical College of Cornell University on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the discovery and mechanism of lipid scramblases — proteins that catalyze the translocation of polar lipids across cell membrane bilayers. The research addresses fundamental questions about scramblase molecular identity, mechanisms of action, physiological contributions, and...
The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $336,000 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate apical junction fluidity control during epithelial morphogenesis. The research examines the role of Prickle 2 (PK2), a core component of the planar cell polarity pathway, in controlling the flexibility and directionality of junctional remodeling. The work focuses on understanding how epithelial tissues deform in response to mechanical cues—including how cells sense forces, transduce those signals to junction-remodeling machinery, and reorganize actomyosin structures. The research addresses the mechanisms underlying anisotropic force generation and directional epithelial deformations, with implications for understanding neural tube closure and other developmental morphogenesis events. Performance occurs in New York, New York with a period of performance through June 30, 2030. The award is classified as a Project Grant, the standard R01 mechanism for investigator-initiated biomedical research supported by NIGMS to advance fundamental scientific discoveries in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $336.0k | 9/3/26 |