Project Grant R01GM160691
- The National Institute of General Medical Sciences, National Institutes of Health, awarded the University of Florida $422,125 on August 15, 2026, to develop rapid, wash-free fluorescent signal-switching methods for high-plex RNA imaging in cells and tissues under the Biomedical Research and Research Training program (CFDA 93.859). The research addresses limitations in current multiplexed fluorescence imaging by establishing a DNA displacement reaction-based signal exchange (DIRSE) platform...
- The National Institute of General Medical Sciences awarded the University of Florida $386,985 on July 23, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct a five-year investigation into the structure-function relationships of single-stranded DNA (ssDNA) in biological systems. The research will develop methods to probe structured ssDNA in cells, with initial focus on two biomedically relevant lines of investigation. The first examines complex ssDNA...
- The National Institute of General Medical Sciences awarded the University of Florida $422,125 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of schlafen-mediated phage defense. The award funds two projects examining how schlafen nucleases function as an ancient antiviral defense mechanism. Project 1 determines the molecular, structural, and biochemical basis of schlafen immunity in bacterial systems. Project...
- The National Institute of General Medical Sciences awarded the University of Florida $383,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct basic research on post-translational modification systems in archaea, with performance through January 31, 2031, at Gainesville, Florida. The project advances understanding of how post-translational modifications coordinate to regulate stress response in the archaeon Haloferax volcanii. Three...
- The National Institute of General Medical Sciences awarded the University of South Florida $474,102 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct synthetic biology and genome engineering of polyketide natural products, develop bioactive metabolites from Antarctic marine invertebrates and deep-sea organisms, synthesize chemical analogs to modulate toxicity and enhance drug-like properties, and advance compound development initiatives...
- The National Institute of Allergy and Infectious Diseases awarded $488,238 to the University of Florida on August 25, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the impacts of Staphylococcus aureus nitric oxide synthase on bacterial survival and physiological adaptation in host environments. The research addresses how bacterial nitric oxide synthase (BNOS) regulates S. aureus metabolism, stress resistance, and virulence factor expression....
- The National Institute of General Medical Sciences awarded the University of Florida $411,407 on August 15, 2026, to develop a bioanalytical platform for monitoring and modeling sepsis immunopathology under the Biomedical Research and Research Training program (CFDA 93.859). The funded research establishes an integrated platform to capture ultrasensitive, longitudinal biochemical monitoring of immune effectors in sepsis patients and develop dynamic disease models linking biochemical trends to...
- The National Institute of General Medical Sciences awarded the University of Florida $1,892,969 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel mass spectrometry technologies for high-resolution molecular imaging of tissue samples. The research addresses critical deficiencies in imaging mass spectrometry (IMS) by advancing chemistries and next-generation analytical techniques that improve both chemical differentiation and spatial...
- The National Institute of General Medical Sciences awarded the University of Florida $398,545 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how active and silenced transposable elements shape meiotic recombination in maize and rice. The research will generate high-resolution crossover maps and perform genome-wide assessment of recombination frequency near transposon insertions, examine whether transposon-derived double-strand...
- Federal Project Grant Award Summary Florida State University's Sponsored Research Administration Division received a $616,401 Project Grant award effective September 1, 2025, through August 31, 2027, under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental research investigating enzyme recruitment—the process by which existing enzymes are enlisted to perform new metabolic functions. The...
The National Institute of General Medical Sciences awarded the University of Florida $322,252 on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover and characterize small molecule inhibitors of bacterial ribonuclease P (RNase P), a tRNA processing enzyme. Work is performed in Gainesville, Florida through April 30, 2030. The project integrates structural biology, biochemistry, and computation to develop small molecule inhibitors targeting RNase P, leveraging the enzyme's well-ordered structure and essential cellular role. The research team has previously solved cryo-EM structures of type A RNase P from Escherichia coli bound to precursor tRNA and higher-resolution structures of Staphylococcus aureus and Enterococcus faecium RNase P, which contain type B class P RNA. These structures reveal multiple well-ordered pockets suitable for small molecule binding. Assay-based high throughput screening has identified five novel scaffolds as active inhibitors of S. aureus RNase P. The work compares bacterial P RNA, which comprises a conserved core and phylogenetically divergent peripheral domains, to human P RNA, which is structurally less complex and requires ten proteins for catalytic activity. The University of Florida Division of Sponsored Research administers the award. This is a Project Grant, the standard NIH R01 research mechanism supporting investigator-initiated biomedical research of high scientific merit as determined by peer review.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $322.3k | 8/5/26 |