Project Grant R01GM157795
- Federal Grant Award Summary Carnegie Mellon University received a $483,012 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 5, 2025, with completion targeted for July 31, 2027. This research initiative systematically characterizes, models, and evaluates the sustainability of biomedical open-source software (OSS) infrastructure that supports modern health research. The...
- Federal Grant Award Summary Carnegie Mellon University received a $300,000 Project Grant from the National Science Foundation's Division of Biological Infrastructure under the Biological Sciences program (CFDA 47.074), effective August 1, 2025 through July 31, 2027. The award supports development of probabilistic string similarity sketching software and mathematical frameworks for genomic sequence analysis. Primary deliverables include rigorous mathematical proofs validating existing genome...
- Federal Grant Award Summary Carnegie Mellon University received a $742,854 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective June 10, 2025 through February 28, 2030. The award funds the development of novel high-throughput machine learning approaches to analyze cell population-wide differences in subcellular object morphology, conformations, and spatial organization derived from...
- Summary Carnegie Mellon University received a $412,295 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. The award supports research advancing sequence transformation theory and microbiology applications, specifically focusing on developing mathematical frameworks and computational tools for analyzing approximate sequence matches in...
- Federal Project Grant Award Summary Carnegie Mellon University received a $380,771 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 10, 2025, through July 31, 2030. Under this five-year research initiative led by Dr. Sevenler, the University will conduct quantitative research on mechanoporation—a process that temporarily increases cell membrane permeability through brief...
- Federal Grant Award Summary Carnegie Mellon University received a $417,450 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on August 12, 2025, with a completion date of May 31, 2030. The grant supports fundamental research investigating the mechanisms of bacterial lysis sensing—a novel process by which bacteria detect threats from related species and respond by forming protective...
- Federal Grant Award Summary The University of Michigan has received a $424,264 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025 through May 31, 2030. This award supports the development of advanced quantitative analysis methodologies for long-read RNA-sequencing (RNA-seq) data at both bulk and single-cell dimensions. The research will advance understanding of gene...
- Federal Grant Award Summary Carnegie Mellon University received a $286,326 project grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective June 10, 2025, with a completion date of May 31, 2026. The award supports the development of integrative machine learning methods for analyzing spatial transcriptomics data generated by NIH Common Fund programs, specifically the Human BioMolecular Atlas Program (HubMAP) and...
- Federal Project Grant Award Summary Carnegie Mellon University received a $225,000 Project Grant award dated August 15, 2025, under the National Science Foundation's Biological Sciences program (CFDA 47.074), administered by the Division of Biological Infrastructure. This collaborative research award, extending through July 31, 2028, supports the development of cyberinfrastructure for analyzing cryo-electron tomography (cryo-ET) data. The primary deliverables include an open-access, annotated...
- Federal Grant Award Summary The University of Pittsburgh received a $437,250 Project Grant awarded August 15, 2025, by the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). The five-year project, concluding July 31, 2030, focuses on developing advanced computational approaches for integrating single-cell multi-omics data across diverse research cohorts. The research addresses critical challenges in precision medicine by...
Carnegie Mellon University received a $315,005 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026, through April 30, 2030. The award funds development of a modular read mapper framework designed to accelerate innovation in genomic sequence analysis. The primary deliverable is a high-performance, modular read mapping platform that serves as a research testbed enabling researchers to readily test and implement new algorithmic approaches to read mapping—the critical computational process of aligning millions of sequencing reads to reference genome sequences. The system will feature a modular architecture permitting easy substitution of novel techniques across various subcomponents, along with a flexible build system enabling lightweight distribution of new mappers without requiring duplication of existing popular mapping tools. The research framework will be implemented using literate programming techniques to facilitate clarity and extensibility for the research community. By reducing the software engineering burden associated with testing new read mapping algorithmic ideas, this platform directly addresses a significant bottleneck in genomic research innovation. The modular mapper will serve as both a modern, production-ready mapping tool and a foundational research platform for advancing the speed and memory efficiency of genomic sequence analysis pipelines, supporting continued improvements in this essential but computationally costly component of genomic research workflows.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $315.0k | 4/29/26 |