Project Grant R01GM157716
- This federal Project Grant award of $413,118.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research on organelle transport and organization in mammalian oogenesis. The research aims to continue investigating how primary oocytes are determined among fetal germ cells during oocyte differentiation, as well as the mechanisms underlying primary oocyte quiescence and loss in adult...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This Project Grant award for $316,368.00 was provided by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant will fund research to understand the mechanisms of metabolic adaptation in cells, focusing on the autophagy and cytochrome P450 pathways. The research aims to elucidate how these pathways respond to nutrient scarcity and chemical stressors, using advanced genomics,...
- This Project Grant award of $147,486.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to reconstitute the synaptonemal complex (SC) of the nematode Caenorhabditis elegans in vitro using a bacterial protein expression system. The award recipient, The Johns Hopkins University, aims to use the purified SC components to study the molecular architecture and assembly mechanisms of this...
- This Project Grant award of $434,679 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research on nuclear envelope dynamics and meiotic quality control mechanisms in the nematode Caenorhabditis elegans. The principal investigator at Lehigh University aims to elucidate how the nuclear envelope and mechanosensitive ion channels like PIEZO transduce signals during meiosis to promote apoptosis when...
- This Project Grant award for $919,914 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research by the Magee-Womens Research Institute and Foundation in Pittsburgh, Pennsylvania to investigate the regulation of meiotic crossover formation across eukaryotic organisms. The research aims to elucidate the interactions and regulation of the core machinery involved in the formation...
- This federal Project Grant award of $404,058.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on investigating the mechanisms that regulate the formation of crossovers on meiotic chromosomes. The research aims to use single-molecule imaging techniques to understand how the dynamics of proteins that control crossover formation create coordinated patterns along...
- This Project Grant award, valued at $1,843,775.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to identify and characterize DNA-protein cross-links (DPCs) and their associated repair pathways. The principal investigator at the University of Kansas Center for Research Inc. will use advanced mass spectrometry techniques to profile the molecular signatures of DPCs across...
- This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand how ubiquitin-mediated post-translational modifications regulate the assembly and function of the kinetochore, a critical protein complex involved in chromosome segregation during cell division. The $232,176 award to the Fred Hutchinson Cancer Center in Seattle, WA, will fund a comprehensive...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $952,117.00 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the role of the nutrient transporter SLC38A2 in regulating meiotic division in mammalian germ cells. The project aims to elucidate the signaling pathways that connect SLC38A2 expression with the initiation of meiosis, building on prior research demonstrating the influence of nutrient restriction and autophagy on meiotic processes in both yeast and mammals. The award, effective from September 1, 2025 to August 31, 2027, will support fundamental scientific research to enhance the understanding of how nutrient sensing and transport mechanisms regulate the critical transition from mitosis to meiosis in eukaryotic cells.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $952.1k | 8/28/25 |