The National Institute of General Medical Sciences (NIGMS) awarded a $254,919 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, San Diego (UCSD) to study the regulatory mechanisms that ensure accurate transmission of the genome during cell division. The research will focus on two key areas: 1) investigating how cells regulate the loading and removal of the Mini-Chromosome Maintenance (MCM) complex to prevent incomplete DNA replication, a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $225,852 to The Leland Stanford Junior University to investigate the mechanisms that promote and ensure reliable formation of meiotic crossovers (COs) in the C. elegans experimental system. The research aims to illuminate fundamental mechanisms that direct orderly chromosome segregation and ensure faithful genome inheritance....
This $380,495.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms and factors that promote aberrant DNA repair at meiotic double-strand breaks, leading to the formation of de novo structural variants in the germline. The research program, conducted by the Regents of the University of Michigan, will address how closely spaced DNA double-strand breaks...
The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research to develop novel approaches for mapping the folding and protein occupancy of entire chromosomes with single-nucleosome resolution and single-molecule precision. The project, titled "Proximity Copy Paste: A Methodology for Single-Molecule Analysis of Chromosome Structure", will employ...
This $438,629 federal Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The goal of the research is to characterize fundamental and conserved mechano-molecular mechanisms of cell division. The project will combine advanced live-cell imaging, molecular, and biochemical methods to investigate the functional contributions of extremely large intrinsically disordered regions in proteins at...
This $616,786 Project Grant was awarded on June 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support research conducted by The Regents of the University of California, San Francisco (UCSF) to uncover the evolutionary mechanisms driving phenotypic variation in human populations. Key areas of investigation include the effects of recessive deleterious alleles and associative...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $433,928 to support research on the molecular mechanism of interphase nuclear pore complex (NPC) assembly. The project aims to develop a spatiotemporal integrative model of human NPC assembly by modeling static snapshots of intermediate assembly states, connecting them into assembly trajectories, and refining the model through...
The Regents of the University of California, San Francisco (UCSF) received a $284,636 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The two-year award will support research establishing novel tools to artificially manipulate chromosome folding and modulate various genome functions, including enhancer regulation of gene expression. Specifically, the grant will fund...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $275,581 to Colorado State University to study the mechanisms and functions of three-dimensional chromatin structures in quiescent cells. The research aims to expand current projects examining how chromatin structure, including condensin-mediated loop domains and histone deacetylation-driven chromatin fiber compaction,...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,286,156 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Trustees of the University of Pennsylvania. The grant, awarded on September 1, 2024, will support a 5-year research project to advance the understanding of cytokinesis and the septin cytoskeleton. The research aims to address core issues regarding the architecture and constriction mechanism of the actomyosin ring, the mechanism of...