This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $316,226 to Cornell University to advance the development of peptide-based proteolysis targeting chimeras (PepTACs) for enhanced targeted protein degradation. The key objectives are to: 1) identify the optimal location of the E3 ligand within the PepTAC structure to promote increased ubiquitination and protein degradation, 2) investigate how PepTAC structure impacts lipid nanoparticle (LNP) loading, stability, and intracellular transport, and 3) develop a universal strategy for improving PepTAC loading into LNPs to enhance systemic stability and delivery. This research aims to unlock the potential of PepTACs as tools for targeted protein degradation and expand the availability of peptide-based protein degraders. The project period runs from July 15, 2024 to May 31, 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $316.2k | 7/8/24 |