Project Grant R01GM153949

Award Date 9/10/24
Completion Date 6/30/29
Dollars Obligated $671K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Aurora, CO 80045, USA
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This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $670,804 to investigate the mechanisms behind increased liver damage in older individuals following burn injuries. The award will fund research at the University of Colorado-Denver to:

  1. Examine how the protein MCJ alters mitochondrial respiration in liver cells of aged mice after burn injuries, potentially leading to liver damage.
  2. Evaluate the role of pro-inflammatory cytokines in post-burn mitochondrial dysfunction and MCJ upregulation.
  3. Explore a novel treatment using small interfering RNA to silence MCJ in liver cells as a strategy to reduce post-burn liver damage in aged mice.

The project also aims to evaluate the potential of MCJ mRNA levels as a biomarker of liver damage in burn patients. This research seeks to develop innovative therapeutic approaches and diagnostic tools to address the heightened mortality rates and liver complications experienced by older burn victims compared to younger patients.

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