This federal Project Grant award of $572,254 from the National Cancer Institute (NCI) under the Cancer Treatment Research (CFDA 93.395) program is focused on identifying selective small molecule inhibitors of the PLCG1 and PLCG2 enzymes, which have been implicated in driving oncogenesis. The key products and services to be delivered under this 3-year award include: Screening a library of 200,000 compounds against PLCG1 and PLCG2 using high-throughput biochemical assays with novel fluorescent...
The National Institute of General Medical Sciences (NIGMS) awarded a $694,875 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to Trustees of Boston University (Boston University Medical Campus). The grant, with a project period from February 1, 2025 to January 31, 2030, will support research to understand the molecular mechanisms that impart plasticity to G protein-coupled receptor (GPCR) and heterotrimeric G protein signaling. The research...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,538,932 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the University of California, Irvine. The 5-year grant, which commenced on September 10, 2024, will support research to elucidate the molecular mechanisms by which protein phosphatase 2A (PP2A) family phosphatases, including PP2A, PP4, and PP6, respond to environmental signals. The research aims to provide...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $445,000.00 in funding to the Beckman Research Institute of the City of Hope to conduct research on the role of allostery in the function of G protein-coupled receptors (GPCRs) and trimeric G proteins. The key research objectives include: 1) Dissecting the structural basis of allosteric modulation by the third...
The National Institute of General Medical Sciences (NIGMS) awarded Purdue University a $268,725 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The objective of this 5-year grant, starting July 1, 2025, is to provide predoctoral students with cross-disciplinary training at the chemical-biology interface as it pertains to drug discovery. The Purdue Drug Discovery Training Program will utilize an integrated curriculum, embedding projects,...
The federal Project Grant award R35GM154623, totaling $401,250.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The grant aims to leverage an integrated proteomic, molecular, genetic, and bioinformatic approach to achieve a mechanistic understanding of how PNET1, a newly identified and evolutionarily conserved nuclear pore complex (NPC) membrane component, impacts mitotic progression in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $452,192 to Vanderbilt University to develop pan- and phospho-specific nanobodies for investigating MAPK and PP2A signaling. The award period runs from June 1, 2025 to March 31, 2029. The project aims to advance scientific understanding of protein phosphorylation, which is a critical cellular process. By creating specialized...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $415,000.00 to Sanford Research to conduct research on the structure and function of G protein-coupled receptors (GPCRs). The research aims to gain a deeper understanding of GPCR signaling pathways and their physiological functions, which are critical for drug development as GPCRs are prime targets. The project...
This $146,922 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program supports research to develop new methods for synthesizing fluorinated chemical compounds. The key objectives are to optimize electrochemical conditions to generate a diverse range of sulfonyl fluorides and aryl fluorides, which have important applications in medicinal chemistry and chemical biology. The research aims to...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,553,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, Berkeley (UC Berkeley) effective September 1, 2024. The grant will fund research to identify calcium ion (Ca2+) channels and transporters that control dynamic changes in cytosolic Ca2+ levels, and uncover regulatory mechanisms for how these Ca2+-transporting proteins are regulated by external cues. The research...