Project Grant R01EY037682
- This $638,625 Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) to the University of California, San Diego (UC San Diego) aims to investigate the mechanism of drusen formation in age-related macular degeneration (AMD). The research will utilize a novel Bruch's membrane-on-a-chip assay developed by the university to study the retention of lipoproteins in the extracellular matrix, which is believed to contribute to drusen accumulation in the early and intermediate...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) is providing $658,889 to the University of Rochester to investigate the role of the secretory phospholipase A2-IIA (PLA2G2A/sPLA2-IIA) enzyme in the development of age-related macular degeneration (AMD). The research aims to critically evaluate the pathogenic role of PLA2G2A in AMD using human donor eyes, patient-derived induced pluripotent stem cells, and transgenic mouse models. The ultimate goal...
- This Project Grant award, totaling $620,149, was provided by the National Eye Institute under the Vision Research federal grant program (CFDA 93.867) with a performance period from April 1, 2025 to March 31, 2030. The University of Iowa will conduct base editing and prime editing of risk loci in human cells, including iPSC-derived retinal pigment epithelium, retina, and choroid, as well as donor retinal and choroidal explant cultures. The goal is to address fundamental scientific questions...
- This federal Project Grant award of $240,713 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research into the role of the nuclear-encoded humanin isoform MTRNR2L1 in age-related macular degeneration (AMD). The awardee, The Research Foundation for the State University of New York (RF SUNY), will investigate whether MTRNR2L1 is a protein-coding gene or a long non-coding RNA, and examine its function in regulating mitochondrial activity and cell...
- This $244,379 Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) supports research at the University of California, Los Angeles (UCLA) to explore how genetic variation influences disease progression and treatment response in age-related macular degeneration (AMD), a leading cause of vision loss. The project aims to leverage machine learning (ML) and artificial intelligence (AI) techniques to analyze optical coherence tomography (OCT) imaging data and...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $300,016 project grant to Fannin Partners LLC, a Houston-based biomedical research company, to develop SCG3 raptamers as a novel targeted therapy for wet age-related macular degeneration (AMD). Wet AMD is a leading cause of vision loss, affecting over 1.25 million individuals in the United States. The project aims to create an aptamer-based treatment that targets secretogranin III (SCG3), a...
- This $1,813,621 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to support a research project titled "Nutritional Metabolomics in Age-Related Macular Degeneration and Retinal Integrity". The grant, awarded to The Research Foundation For The State University Of New York (RF SUNY), will fund the analysis of approximately 2,000 metabolites from participant serum samples to examine the relationship between...
- This Project Grant award of $253,500.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The researchers will optimize an in vitro human outer blood-retina barrier model to study AMD phenotypes and...
- This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides USD 521,572.00 to East Tennessee State University to investigate the role of histone expression in retinal pigment epithelium (RPE) aging and its relationship to age-related macular degeneration (AMD). The research aims to define signatures of histone expression in the aging RPE and determine the cellular effects of histone depletion on RPE homeostasis and AMD progression....
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to study the impact of sex on mitochondrial and epigenetic mechanisms in age-related macular degeneration (AMD), a leading cause of irreversible vision loss. The $547,898 award, granted to The Research Foundation for the State University of New York (RF SUNY), will support research to better understand the heterogeneity of AMD and identify potential therapies to...
This federal Project Grant award of $675,193 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at Duke University on gene therapy targeting complement factor H (CFH) and lipoprotein dynamics in age-related macular degeneration (AMD). The research aims to leverage novel animal models that integrate advanced age, complement dysregulation, and lipid/cholesterol perturbation to understand the contributions of these factors to AMD pathogenesis. The award period runs from Sep 1, 2025 to Jun 30, 2028. The research seeks to elucidate the functional consequences of the Y402H polymorphism in CFH, which is a key genetic risk variant for AMD, and its effects on lipoprotein levels and the development of an AMD-like phenotype in aged mice. The findings could inform the development of potential therapeutic interventions for AMD, the leading cause of irreversible blindness in the elderly.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $675.2k | 8/18/25 |