This $393,008 federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research at the University of California, Davis (UC Davis) to systematically investigate the mechanisms underlying successful axonal regeneration in the retinal ganglion cells (RGCs) of the frog Xenopus laevis.
The research aims to delineate the intrinsic pathways involving the genes DLK and SARM1 that are critical for conveying injury signals and enabling axon removal and regeneration. Additionally, the project will leverage live imaging techniques to elucidate the role of myeloid cells in the successful regeneration process. This work has the potential to yield insights that could advance the development of therapies for promoting axon regeneration, a key challenge in translating RGC regeneration research from animal models to clinical applications. The grant award period is from January 1, 2025 through December 31, 2029.
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