Project Grant R01EY036824
- This Project Grant award, provided by the National Eye Institute (CFDA 93.867 - Vision Research), is supporting research at The University of Iowa to enable the production of autologous (patient-derived) cell therapies for treating inherited retinal degenerative blindness. The $618,600 award, effective from March 1, 2025 to February 28, 2030, aims to address key challenges in the manufacturing of these personalized cell therapies, such as assessing retinal differentiation capacity and...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research grant program (CFDA 93.867), provides $477,109.00 in funding to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on gene regulation underlying photoreceptor neurodegeneration in retinal degenerative diseases. The project aims to determine how the transcriptional regulator PRDM13 regulates retinal development and its association with North Carolina macular...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $475,442 to the University of California, Los Angeles (UCLA) to conduct research focused on understanding the mechanisms underlying the ingestion of photoreceptor outer segment tips by the retinal pigment epithelium (RPE). The research aims to investigate the dynamic actin polymerization and trogocytosis process involved in this essential cellular function, as well as the daily timing of outer...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $306,814 to Piximune, Inc. to develop an antibody-based, gene-agnostic treatment for inherited retinal degeneration, such as retinitis pigmentosa. The proposed approach aims to augment natural mechanisms that eliminate toxic cellular debris from dead and dying photoreceptor cells, thereby protecting surrounding functional cells and preventing secondary retinal damage independent of the causal...
- This $415,012 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports research to elucidate the competence and fate choice dynamics during retinal development. The University of Colorado-Denver, the awardee, will investigate how the Notch signaling pathway regulates multiple different fate decisions throughout retinal development. This research aims to improve understanding of the probabilistic nature of retinal cell fate specification, which is critical for...
- This $146,922 project grant award from the National Eye Institute's Vision Research program (CFDA 93.867) supports research at The Johns Hopkins University to understand the chromatin architectural landscape of retinal development at the single-cell level. The project aims to identify how transcription factors manipulate genomic structure to control cell fate specification in the retina, a model system for studying neuronal development. Specifically, the research will use single-cell Hi-C and...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $144,200 Project Grant to Pennsylvania State University's Milton S. Hershey Medical Center. The grant, effective June 1, 2025 through November 30, 2027, will fund research to characterize the molecular mechanisms underlying increased levels of the protein REDD1 in the retina due to diabetes, and explore alternative intervention strategies for preventing retinal complications caused by...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports the development of a novel, noninvasive, and sensitive diagnostic method to measure retinal dysfunction. The $491,466 award will fund research at the University of California, San Francisco (UCSF) from January 1, 2025 to December 31, 2026. The project aims to create a scalable diagnostic tool that can detect the earliest signs of retinal diseases like diabetic retinopathy and retinitis pigmentosa,...
- This federal Project Grant award of $428,349 from the National Eye Institute's Vision Research program (CFDA 93.867) supports research into the mechanistic assessment of retinal ganglion cell genesis. The award, with a performance period from July 1, 2025 to March 31, 2030, aims to investigate the shared gene regulatory network and downstream targets of the key transcription factors Atoh7, Pou4f2, and Isl1 that are required for proper retinal ganglion cell development. The research will be...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, provides $590,160.00 in funding to characterize photoreceptor precursor cells for retinal transplantation. The research aims to improve understanding of photoreceptor development and investigate avenues for photoreceptor regeneration to restore vision, as retinal degenerative diseases can lead to irreversible vision loss. The project will perform lineage tracing of distinct photoreceptor precursor cell subpopulations identified through single cell transcriptomics, and evaluate their efficiency for integration upon subretinal transplantation in a mouse model of retinal degeneration. This 5-year research effort commenced on September 1, 2025 and is scheduled for completion on April 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $590.2k | 8/11/25 |