This Project Grant award for $684,891.00 was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867). The award to the Massachusetts Eye and Ear Infirmary, a non-profit hospital and research center affiliated with Harvard Medical School, will fund research to address the challenge of interpreting rare genetic variants of unknown significance in inherited retinal degenerations. The project aims to develop a high-throughput splicing assay to...
This federal Project Grant award of $715,098 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) aims to enhance glaucoma risk prediction through advanced genomics and machine learning. The key products and services to be delivered include: Improving polygenic risk score (PRS) performance for glaucoma by leveraging natural language processing techniques and electronic health record data from over 68,000 patients to extract refined glaucoma phenotypes. The...
This federal Project Grant award from the National Eye Institute (NEI), under CFDA program 93.867 "Vision Research", provides $2,305,702 to Vanderbilt University Medical Center to conduct an integrative multi-omics study to discover molecular pathways associated with diabetic retinopathy. The study aims to quantify differential transcript and metabolite abundance between participants with type 2 diabetes with and without diabetic retinopathy, and replicate the findings in an...
The National Eye Institute (NEI) awarded a $666,276 Project Grant (CFDA 93.867 - Vision Research) to Vanderbilt University to investigate the neuronal mechanisms by which stimulation of the nucleus basalis of Meynert can improve visual working memory and attention in primates. The project aims to understand how this cholinergic stimulation affects the activity of neurons in the dorsolateral prefrontal and posterior parietal cortex during the performance of visual cognitive tasks. The research...
The National Eye Institute (NEI) awarded a $125,916 Project Grant (CFDA 93.867 - Vision Research) to the University of California, Davis to study the transcriptional and developmental basis of an X-linked homeotic hotspot associated with bilateral anophthalmia (missing eye globes) and XX sex reversal syndrome. The research will leverage in vitro analysis of patient-derived blood cells and induced pluripotent stem cells, as well as in vivo characterization of a mouse model, to investigate the...
This $521,572 Project Grant award was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to East Tennessee State University (ETSU). The grant aims to define signatures of histone expression in the aging retinal pigment epithelium (RPE) and determine the cellular effects of histone depletion on RPE homeostasis and age-related macular degeneration (AMD) progression. Key activities include using RNA-sequencing, ChIP-sequencing, and other...
This $1,789,542.00 federal Project Grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to identify and characterize the regulatory mechanisms controlling the expression of key early retinal transcription factor genes during development in the murine and human retina. The research team at St. Jude Children's Research Hospital, the grant recipient, will test the hypothesis that the SIX3/SIX3 and OTX2/OTX2 genes are regulated by...
The National Eye Institute (NEI) awarded a $388,750 Project Grant under the Vision Research program (CFDA 93.867) to The Washington University in St. Louis. The five-year grant, effective August 1, 2024, will fund research to investigate the role of the histone variant H3.3 in retinal cell fate specification and differentiation. The research aims to complete a full phenotypic characterization of retinal development upon loss of H3.3 from retinal progenitors and post-mitotic neurons, as well as...
This $477,109.00 Project Grant award from the National Eye Institute (NEI) under the NIH's Vision Research grant program (CFDA 93.867) supports research at the University of Texas Southwestern Medical Center to investigate how the PRDM13 transcriptional regulator controls retinal cell fate determination and photoreceptor development. The goal is to better understand the molecular mechanisms underlying retinal degeneration, with the potential to inform future clinical therapies for preserving...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) totaling $1,298,882.00 to the University of Oklahoma Health Sciences Center to investigate extracellular microRNA-mediated communication between retinal pigment epithelium (RPE) and microglia. The primary goals are to study the transfer of extracellular microRNAs between these two cell types and evaluate the use of engineered RPE-derived extracellular vesicles as a strategy to mitigate retinal inflammation...