Project Grant R01EY036247

Award Date 7/1/24
Completion Date 6/30/28
Dollars Obligated $1.3M
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Tucson, AZ 85721, USA
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The Project Grant award R01EY036247, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), is focused on repurposing and reformulating the drug adefovir dipivoxil (ADV) for improved topical treatment of herpes simplex virus (HSV) infection of the eye. The total funding for this 4-year project is $1,313,945, with the award beginning on Jul 1, 2024.

The key objectives are to: 1) evaluate ADV solution compared to currently approved topical anti-herpetic drugs like ganciclovir and trifluridine using ex-vivo ocular permeability studies, ocular pharmacokinetics in rabbits, and in vivo efficacy in a mouse model of ocular herpes; and 2) develop and characterize nanoparticle suspensions of various hydrophobic ADV salts, and assess their in vitro cytocompatibility, in vitro antiviral activity, ex vivo corneal permeability, ocular pharmacokinetics in rabbits, and in vivo efficacy in a rabbit model of ocular herpes. The successful completion of this project is expected to lead to the development of a clinically viable, patient-friendly long-acting topical nanomedicine for the effective management of ocular herpes infections.

A sub-award of $770,317 was provided to the University of Illinois to collaborate on this project.

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