The University of Miami's Office of Research Administration - School of Medicine Division received a $432,700 Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867). The funding supports a research study investigating the mechanisms by which the cytokine IL-27 regulates inflammation and promotes photoreceptor survival during retinal degeneration. The study aims to define how IL-27 signaling controls inflammation and protects photoreceptors, as well as identify whether a novel Müller glia-microglia cytokine-cytokine receptor axis mediates IL-27's protective effects. The 4-year project, which commenced on May 1, 2024, seeks to generate new insights into the regulation of retinal inflammation and provide a foundation for developing IL-27 as a potential therapeutic strategy to preserve vision during retinal disease.
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