The National Eye Institute (NEI) awarded a $1,018,210 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) for a 5-year research project from July 1, 2024 to June 30, 2029. The project aims to enhance the understanding of the pathogenesis of uveitis, an inflammatory eye disease, in order to improve uveitis classification, diagnosis, biomarker identification, and the characterization of the host response. The researchers will perform worldwide surveillance of pathogens causing uveitis, identify geographic trends, and assess the impact of pathogen class and antimicrobial resistance on visual outcomes. Additionally, they will characterize the host gene expression profiles in infectious uveitis and identify transcriptome signatures that predict clinical outcomes. The final aim is to discover non-invasive biomarkers in tears using proteome and metabolomic analysis. This comprehensive multi-omics approach seeks to advance the diagnosis and management of uveitis.
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